4LOP

Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form)

Summary for 4LOP

• Entry DOI: 10.2210/pdb4lop/pdb
• Descriptor: Mitogen-activated protein kinase 14, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, ... (6 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, protein kinase, kinase-regulatory protein complex, mapk, autoactivation, autophosphorylation, transferase
• Biological source: Mus musculus (mouse); More
• Cellular location: Cytoplasm: P47811
• Total number of polymer chains: 8
• Total formula weight: 180575.63

Authors

Chaikuad, A.,DeNicola, G.F.,Krojer, T.,Allerston, C.K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Marber, M.S.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-07-13, release date: 2013-08-21, Last modification date: 2023-09-20)

• Primary citation: De Nicola, G.F.,Martin, E.D.,Chaikuad, A.,Bassi, R.,Clark, J.,Martino, L.,Verma, S.,Sicard, P.,Tata, R.,Atkinson, R.A.,Knapp, S.,Conte, M.R.,Marber, M.S.; Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1.; Nat.Struct.Mol.Biol., 20:1182-1190, 2013; PubMed: 24037507; DOI: 10.1038/nsmb.2668

Experimental method

X-RAY DIFFRACTION (2.049 Å)