4JQ7
Crystal structure of EGFR kinase domain in complex with compound 2a
Summary for 4JQ7
Entry DOI | 10.2210/pdb4jq7/pdb |
Descriptor | Epidermal growth factor receptor, (2S)-2-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)amino]-2-phenylethanol (3 entities in total) |
Functional Keywords | transferase, tyrosine kinase domain, atp-binding domain, autophosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 37808.71 |
Authors | Peng, Y.H.,Wu, J.S. (deposition date: 2013-03-20, release date: 2013-06-19, Last modification date: 2023-11-08) |
Primary citation | Peng, Y.H.,Shiao, H.Y.,Tu, C.H.,Liu, P.M.,Hsu, J.T.,Amancha, P.K.,Wu, J.S.,Coumar, M.S.,Chen, C.H.,Wang, S.Y.,Lin, W.H.,Sun, H.Y.,Chao, Y.S.,Lyu, P.C.,Hsieh, H.P.,Wu, S.Y. Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors J.Med.Chem., 56:3889-3903, 2013 Cited by PubMed: 23611691DOI: 10.1021/jm400072p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.73 Å) |
Structure validation
Download full validation report