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4G0V

Human topoisomerase iibeta in complex with DNA and mitoxantrone

Summary for 4G0V

Related3QX3 4G0U 4G0W 4J3N 
DescriptorDNA topoisomerase 2-beta (E.C.5.99.1.3)/DNA complex, Mitoxantrone
Functional KeywordsTOPRIM domain, winged-helix domain, coiled-coil domain, DNA-binding and cleavage, nucleus, ISOMERASE-DNA-ISOMERASE INHIBITOR complex,ISOMERASE/DNA/ISOMERASE INHIBITOR
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm 
Organ source
Total number of polymer chains6
Total molecular weight197075.21
Authors
Wu, C.C.,Li, T.K.,Li, Y.C.,Chan, N.L. (deposition date: 2012-07-10, release date: 2013-07-17, modification date: 2014-03-12)
Primary citation
Wu, C.C.,Li, Y.C.,Wang, Y.R.,Li, T.K.,Chan, N.L.
On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41:10630-10640, 2013
PubMed: 24038465
DOI: 10.1093/nar/gkt828
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.548 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.20540.2%0.7%3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolutionDownload full validation report

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104371
entries available on 2014-10-22
00:00 UTC / 09:00 JST