4FDD

Crystal structure of KAP beta2-PY-NLS

Summary for 4FDD

• Entry DOI: 10.2210/pdb4fdd/pdb
• Related: 1qbk 2OT8 2QMR 2h4m
• Descriptor: Transportin-1, RNA-binding protein FUS (3 entities in total)
• Functional Keywords: heat repeats, karyopherin, nuclear import, protein transport, importin, transportin, transport protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q92973; Nucleus : P35637
• Total number of polymer chains: 2
• Total formula weight: 99919.22

Authors

Zhang, Z.C.,Chook, Y.M. (deposition date: 2012-05-28, release date: 2012-07-18, Last modification date: 2024-02-28)

• Primary citation: Zhang, Z.C.,Chook, Y.M.; Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS).; Proc.Natl.Acad.Sci.USA, 109:12017-12021, 2012; PubMed: 22778397; DOI: 10.1073/pnas.1207247109

Experimental method

X-RAY DIFFRACTION (2.3 Å)