4F4P

SYK in COMPLEX WITH LIGAND LASW836

Summary for 4F4P

Entry DOI	10.2210/pdb4f4p/pdb
Descriptor	Tyrosine-protein kinase SYK, N-{6-[3-(piperazin-1-yl)phenyl]pyridin-2-yl}-4-(trifluoromethyl)pyridin-2-amine, SULFATE ION, ... (4 entities in total)
Functional Keywords	tyrosine-protein kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane : P43405
Total number of polymer chains	1
Total formula weight	32088.89
Authors	Lopez, M.,Segarra, V.,Vidal, B.,Wenzkowski, C.,Jestel, A.,Krapp, S.,Blaesse, M.,Nagel, S.,Schreiner, P. (deposition date: 2012-05-11, release date: 2012-12-12, Last modification date: 2024-02-28)
Primary citation	Castillo, M.,Forns, P.,Erra, M.,Mir, M.,Lopez, M.,Maldonado, M.,Orellana, A.,Carreno, C.,Ramis, I.,Miralpeix, M.,Vidal, B. Highly potent aminopyridines as Syk kinase inhibitors. Bioorg.Med.Chem.Lett., 22:5419-5423, 2012 Cited by PubMed: 22877633 DOI: 10.1016/j.bmcl.2012.07.045 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.37 Å)

Structure validation