4YV8

Crystal structure of cathepsin K bound to the covalent inhibitor lichostatinal

Summary for 4YV8

• Entry DOI: 10.2210/pdb4yv8/pdb
• Related: 4YVA
• Related PRD ID: PRD_002162
• Descriptor: Cathepsin K, Lichostatinal, SULFATE ION, ... (4 entities in total)
• Functional Keywords: cathepsin k, lichostatinal, inhibitor, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 24311.30

Authors

Aguda, A.H.,Nguyen, N.T.,Bromme, D.,Brayer, G.D. (deposition date: 2015-03-19, release date: 2016-05-04, Last modification date: 2023-11-15)

• Primary citation: Aguda, A.H.,Lavallee, V.,Cheng, P.,Bott, T.M.,Meimetis, L.G.,Law, S.,Nguyen, N.T.,Williams, D.E.,Kaleta, J.,Villanueva, I.,Davies, J.,Andersen, R.J.,Brayer, G.D.,Bromme, D.; Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts.; J.Nat.Prod., 79:1962-1970, 2016; PubMed: 27498895; DOI: 10.1021/acs.jnatprod.6b00215

Experimental method

X-RAY DIFFRACTION (2 Å)