3WIZ
Crystal structure of Bcl-xL in complex with compound 10
Summary for 3WIZ
Entry DOI | 10.2210/pdb3wiz/pdb |
Related | 3WIX 3WIY |
Descriptor | Bcl-2-like protein 1, 7-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]carbamoyl}-2-methylphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | regulation, apoptosis |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817 |
Total number of polymer chains | 2 |
Total formula weight | 42732.75 |
Authors | Sogabe, S.,Igaki, S.,Hayano, Y. (deposition date: 2013-09-26, release date: 2013-11-27, Last modification date: 2023-11-08) |
Primary citation | Tanaka, Y.,Aikawa, K.,Nishida, G.,Homma, M.,Sogabe, S.,Igaki, S.,Hayano, Y.,Sameshima, T.,Miyahisa, I.,Kawamoto, T.,Tawada, M.,Imai, Y.,Inazuka, M.,Cho, N.,Imaeda, Y.,Ishikawa, T. Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins. J.Med.Chem., 56:9635-9645, 2013 Cited by PubMed: 24215352DOI: 10.1021/jm401170c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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