3VBG
Structure of hDM2 with Dimer Inducing Indolyl Hydantoin RO-2443
Summary for 3VBG
| Entry DOI | 10.2210/pdb3vbg/pdb |
| Related | 1RV1 3U15 |
| Descriptor | E3 ubiquitin-protein ligase Mdm2, (5Z)-5-[(6-chloro-7-methyl-1H-indol-3-yl)methylidene]-3-(3,4-difluorobenzyl)imidazolidine-2,4-dione (3 entities in total) |
| Functional Keywords | ligase, mdm2, mdmx, p53, ligase-ligase activator complex, ligase/ligase activator |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 4 |
| Total formula weight | 41850.56 |
| Authors | Lukacs, C.M.,Janson, C.A.,Graves, B.J. (deposition date: 2012-01-02, release date: 2012-06-27, Last modification date: 2023-09-13) |
| Primary citation | Graves, B.,Thompson, T.,Xia, M.,Janson, C.,Lukacs, C.,Deo, D.,Di Lello, P.,Fry, D.,Garvie, C.,Huang, K.S.,Gao, L.,Tovar, C.,Lovey, A.,Wanner, J.,Vassilev, L.T. Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization. Proc.Natl.Acad.Sci.USA, 109:11788-11793, 2012 Cited by PubMed: 22745160DOI: 10.1073/pnas.1203789109 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
Download full validation report
