3V6R
Discovery of potent and selective covalent inhibitors of JNK
Summary for 3V6R
Entry DOI | 10.2210/pdb3v6r/pdb |
Related | 3V6S |
Descriptor | Mitogen-activated protein kinase 10, 4-{[4-(dimethylamino)butanoyl]amino}-N-(3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide (3 entities in total) |
Functional Keywords | kinase fold, apoptosis, map kinase, cys modification, phosphorylation, jnk, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P53779 |
Total number of polymer chains | 2 |
Total formula weight | 85110.50 |
Authors | Park, H.,LoGrasso, P.V.,Laughlin, J.D. (deposition date: 2011-12-20, release date: 2012-02-01, Last modification date: 2012-07-25) |
Primary citation | Zhang, T.,Inesta-Vaquera, F.,Niepel, M.,Zhang, J.,Ficarro, S.B.,Machleidt, T.,Xie, T.,Marto, J.A.,Kim, N.,Sim, T.,Laughlin, J.D.,Park, H.,LoGrasso, P.V.,Patricelli, M.,Nomanbhoy, T.K.,Sorger, P.K.,Alessi, D.R.,Gray, N.S. Discovery of potent and selective covalent inhibitors of JNK. Chem.Biol., 19:140-154, 2012 Cited by PubMed: 22284361DOI: 10.1016/j.chembiol.2011.11.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report