3V3B

Structure of the Stapled p53 Peptide Bound to Mdm2

Summary for 3V3B

• Entry DOI: 10.2210/pdb3v3b/pdb
• Related: 1YCR
• Related PRD ID: PRD_000857
• Descriptor: E3 ubiquitin-protein ligase Mdm2, SAH-p53-8 stapled-peptide, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: oncoprotein, cell cycle, dna repair, cancer, p53-derived peptide, aliphatic staple, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus, nucleoplasm: Q00987
• Total number of polymer chains: 4
• Total formula weight: 25237.15

Authors

Baek, S.,Kutchukian, P.S.,Verdine, G.L.,Huber, R.,Holak, T.A.,Ki Won, L.,Popowicz, G.M. (deposition date: 2011-12-13, release date: 2012-01-18, Last modification date: 2023-11-15)

• Primary citation: Baek, S.,Kutchukian, P.S.,Verdine, G.L.,Huber, R.,Holak, T.A.,Lee, K.W.,Popowicz, G.M.; Structure of the stapled p53 peptide bound to Mdm2.; J.Am.Chem.Soc., 134:103-106, 2012; PubMed: 22148351; DOI: 10.1021/ja2090367

Experimental method

X-RAY DIFFRACTION (2 Å)