3S2K

Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.

Summary for 3S2K

Entry DOI	10.2210/pdb3s2k/pdb
Descriptor	Low-density lipoprotein receptor-related protein 6, Dickkopf-related protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	wnt co-receptor, beta-propeller, egf domain, wnt signaling, wnt inhibitor, glycosylation, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	157566.80
Authors	Ahn, V.E.,Chu, M.L.-H.,Choi, H.-J.,Tran, D.,Abo, A.,Weis, W.I. (deposition date: 2011-05-16, release date: 2011-11-02, Last modification date: 2020-07-29)
Primary citation	Ahn, V.E.,Chu, M.L.,Choi, H.J.,Tran, D.,Abo, A.,Weis, W.I. Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6. Dev.Cell, 21:862-873, 2011 Cited by PubMed: 22000856 DOI: 10.1016/j.devcel.2011.09.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation