3P8H

Crystal structure of L3MBTL1 (MBT repeat) in complex with a nicotinamide antagonist

Summary for 3P8H

Entry DOI	10.2210/pdb3p8h/pdb
Descriptor	Lethal(3)malignant brain tumor-like protein, 3-bromo-5-[(4-pyrrolidin-1-ylpiperidin-1-yl)carbonyl]pyridine, SULFATE ION, ... (5 entities in total)
Functional Keywords	lethal(3) malignant brain tumor-like protein, l(3)mbt-like protein, structural genomics consortium, sgc, mbt repeat, transcriptional repression, methylated lysines on histone proteins, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus : Q9Y468
Total number of polymer chains	3
Total formula weight	112480.56
Authors	Lam, R.,Herold, J.M.,Ouyang, H.,Tempel, W.,Gao, C.,Ravichandran, M.,Senisterra, G.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Vedadi, M.,Kireev, D.,Frye, S.V.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2010-10-13, release date: 2010-11-03, Last modification date: 2023-09-06)
Primary citation	Herold, J.M.,Wigle, T.J.,Norris, J.L.,Lam, R.,Korboukh, V.K.,Gao, C.,Ingerman, L.A.,Kireev, D.B.,Senisterra, G.,Vedadi, M.,Tripathy, A.,Brown, P.J.,Arrowsmith, C.H.,Jin, J.,Janzen, W.P.,Frye, S.V. Small-molecule ligands of methyl-lysine binding proteins. J.Med.Chem., 54:2504-2511, 2011 Cited by PubMed: 21417280 DOI: 10.1021/jm200045v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation