3NWB
Rat COMT in complex with a fluorinated desoxyribose-containing bisubstrate inhibitor avoids hydroxyl group
Summary for 3NWB
Entry DOI | 10.2210/pdb3nwb/pdb |
Related | 3NW9 3NWE 3OZR 3OZS 3OZT |
Descriptor | Catechol O-methyltransferase, MAGNESIUM ION, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | methyltransferase, neurotransmitter degradation, alternative initiation, catecholamine metabolism, cell membrane, magnesium, membrane, metal-binding, phosphoprotein, s-adenosyl-l-methionine, signal-anchor, transmembrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (rat) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734 |
Total number of polymer chains | 1 |
Total formula weight | 25744.92 |
Authors | Ehler, A.,Schlatter, D.,Stihle, M.,Benz, J.,Rudolph, M.G. (deposition date: 2010-07-09, release date: 2011-08-03, Last modification date: 2024-03-20) |
Primary citation | Ellermann, M.,Lerner, C.,Burgy, G.,Ehler, A.,Bissantz, C.,Jakob-Roetne, R.,Paulini, R.,Allemann, O.,Tissot, H.,Grunstein, D.,Stihle, M.,Diederich, F.,Rudolph, M.G. Catechol-O-methyltransferase in complex with substituted 3'-deoxyribose bisubstrate inhibitors Acta Crystallogr.,Sect.D, 68:253-260, 2012 Cited by PubMed: 22349227DOI: 10.1107/S0907444912001138 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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