3E7A
Crystal Structure of Protein Phosphatase-1 Bound to the natural toxin Nodularin-R
Summary for 3E7A
Entry DOI | 10.2210/pdb3e7a/pdb |
Related | 1FJM 1IT6 1JK7 2BCD 3E7B |
Related PRD ID | PRD_000214 |
Descriptor | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, nodularin R, MANGANESE (II) ION, ... (8 entities in total) |
Functional Keywords | carbohydrate metabolism, cell cycle, cell division, glycogen metabolism, hydrolase, iron, manganese, metal-binding, phosphoprotein, protein phosphatase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm: P62136 |
Total number of polymer chains | 4 |
Total formula weight | 72418.71 |
Authors | Kelker, M.S.,Page, R.,Peti, W. (deposition date: 2008-08-18, release date: 2008-11-04, Last modification date: 2023-11-15) |
Primary citation | Kelker, M.S.,Page, R.,Peti, W. Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors J.Mol.Biol., 385:11-21, 2009 Cited by PubMed: 18992256DOI: 10.1016/j.jmb.2008.10.053 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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