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3DWY

Crystal Structure of the Bromodomain of Human CREBBP

Summary for 3DWY

DescriptorCREB-binding protein (E.C.2.3.1.48)
Functional Keywordsbromodomain, CREB binding protein, structural genomics consortium, SGC, Activator, Disease mutation, Host-virus interaction, Metal-binding, Methylation, Nucleus, Phosphoprotein, Transcription, Transcription regulation, Transferase, Zinc-finger,TRANSFERASE
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm 
Organ source
Total number of polymer chains2
Total molecular weight28633.15
Authors
Filippakopoulos, P.,Picaud, S.,Fedorov, O.,Karim, R.,Pike, A.C.W.,Von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Wickstroem, M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-07-23, release date: 2008-08-05, modification date: 2012-04-11)
Primary citation
Filippakopoulos, P.,Picaud, S.,Mangos, M.,Keates, T.,Lambert, J.P.,Barsyte-Lovejoy, D.,Felletar, I.,Volkmer, R.,Muller, S.,Pawson, T.,Gingras, A.C.,Arrowsmith, C.H.,Knapp, S.
Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149:214-231, 2012
PubMed: 22464331
DOI: 10.1016/j.cell.2012.02.013
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.98 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.223302.5%6.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolutionDownload full validation report

More Asymmetric unit images

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105025
entries available on 2014-11-19
00:00 UTC / 09:00 JST