Crystal Structure of the Bromodomain of Human CREBBP

Summary for 3DWY

DescriptorCREB-binding protein (E.C.
Functional Keywordsbromodomain, CREB binding protein, structural genomics consortium, SGC, Activator, Disease mutation, Host-virus interaction, Metal-binding, Methylation, Nucleus, Phosphoprotein, Transcription, Transcription regulation, Transferase, Zinc-finger,TRANSFERASE
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm Q92793
Total number of polymer chains2
Total molecular weight28633.15
Filippakopoulos, P.,Picaud, S.,Fedorov, O.,Karim, R.,Pike, A.C.W.,Von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Wickstroem, M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-07-23, release date: 2008-08-05, modification date: 2012-04-11)
Primary citation
Filippakopoulos, P.,Picaud, S.,Mangos, M.,Keates, T.,Lambert, J.P.,Barsyte-Lovejoy, D.,Felletar, I.,Volkmer, R.,Muller, S.,Pawson, T.,Gingras, A.C.,Arrowsmith, C.H.,Knapp, S.
Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149:214-231, 2012
PubMed: 22464331
DOI: 10.1016/j.cell.2012.02.013
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.223302.5%6.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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rotated about x axis by 90°
rotated about y axis by 90°
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