3DWY

Crystal Structure of the Bromodomain of Human CREBBP

Summary for 3DWY

DescriptorCREB-binding protein (E.C.2.3.1.48)
Functional Keywordsbromodomain, creb binding protein, structural genomics consortium, sgc, activator, disease mutation, host-virus interaction, metal-binding, methylation, nucleus, phosphoprotein, transcription, transcription regulation, transferase, zinc-finger
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm Q92793
Total number of polymer chains2
Total molecular weight28633.15
Authors
Primary citation
Filippakopoulos, P.,Picaud, S.,Mangos, M.,Keates, T.,Lambert, J.P.,Barsyte-Lovejoy, D.,Felletar, I.,Volkmer, R.,Muller, S.,Pawson, T.,Gingras, A.C.,Arrowsmith, C.H.,Knapp, S.
Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149:214-231, 2012
PubMed: 22464331
DOI: 10.1016/j.cell.2012.02.013
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.98 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.221302.5%8.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3dwy
no rotation
Molmil generated image of 3dwy
rotated about x axis by 90°
Molmil generated image of 3dwy
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 3dwy
no rotation
Molmil generated image of 3dwy
rotated about x axis by 90°
Molmil generated image of 3dwy
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3dwy.pdb1.gz [22.88 KB])
Coordinate files for Biological unit (3dwy.pdb2.gz [21.73 KB])
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