3D0A
Human p53 core domain with hot spot mutation R249S and second site suppressor mutation H168R in sequence-specific complex with DNA
Summary for 3D0A
Entry DOI | 10.2210/pdb3d0a/pdb |
Related | 3D05 3D06 3D07 3D08 3D09 |
Descriptor | DNA (5'-D(*DCP*DGP*DGP*DGP*DCP*DAP*DTP*DGP*DCP*DCP*DCP*DG)-3'), Cellular tumor antigen p53, ZINC ION, ... (4 entities in total) |
Functional Keywords | p53, mutant protein, loop-sheet-helix motif, dna target, acetylation, activator, alternative splicing, anti-oncogene, apoptosis, cell cycle, covalent protein-rna linkage, cytoplasm, disease mutation, dna-binding, endoplasmic reticulum, glycoprotein, host-virus interaction, li-fraumeni syndrome, metal-binding, methylation, nucleus, phosphoprotein, polymorphism, transcription, transcription regulation, ubl conjugation, zinc, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 8 |
Total formula weight | 104737.21 |
Authors | Suad, O.,Rozenberg, H.,Shakked, Z. (deposition date: 2008-05-01, release date: 2009-01-20, Last modification date: 2023-11-01) |
Primary citation | Suad, O.,Rozenberg, H.,Brosh, R.,Diskin-Posner, Y.,Kessler, N.,Shimon, L.J.W.,Frolow, F.,Liran, A.,Rotter, V.,Shakked, Z. Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations J.Mol.Biol., 385:249-265, 2009 Cited by PubMed: 18996393DOI: 10.1016/j.jmb.2008.10.063 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report