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2Z8C

Phosphorylated insulin receptor tyrosine kinase in complex with (4-{[5-carbamoyl-4-(3-methylanilino)pyrimidin-2-yl]amino}phenyl)acetic acid

Summary for 2Z8C
Entry DOI10.2210/pdb2z8c/pdb
Related2Z7L
DescriptorInsulin receptor, 6-mer peptide from Insulin receptor substrate 1, [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID (3 entities in total)
Functional Keywordstransferase, alternative splicing, atp-binding, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, glycoprotein, kinase, membrane, nucleotide-binding, phosphorylation, polymorphism, receptor, transmembrane, tyrosine-protein kinase, transducer
Biological sourceHomo sapiens (Human)
More
Cellular locationCell membrane; Single-pass type I membrane protein: P06213
Total number of polymer chains2
Total formula weight35826.57
Authors
Katayama, N.,Kurihara, H. (deposition date: 2007-09-05, release date: 2008-08-12, Last modification date: 2023-11-15)
Primary citationKatayama, N.,Orita, M.,Yamaguchi, T.,Hisamichi, H.,Kuromitsu, S.,Kurihara, H.,Sakashita, H.,Matsumoto, Y.,Fujita, S.,Niimi, T.
Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors.
Proteins, 73:795-801, 2008
Cited by
PubMed: 18767165
DOI: 10.1002/prot.22207
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.25 Å)
Structure validation

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