2QAB

Crystal Structure of Estrogen Receptor Alpha Ligand Binding Domain Mutant 537S Complexed with an Ethyl Indazole Compound

Summary for 2QAB

Entry DOI	10.2210/pdb2qab/pdb
Descriptor	Estrogen receptor, nuclear receptor coactivator 2, 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL, ... (4 entities in total)
Functional Keywords	protein-ligand complex, transcription
Biological source	Homo sapiens (human) More
Cellular location	Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 Nucleus : Q8BN74
Total number of polymer chains	4
Total formula weight	62441.52
Authors	Nettles, K.W.,Bruning, J.B.,Nowak, J.,Sharma, S.K.,Hahm, J.B.,Shi, Y.,Kulp, K.,Hochberg, R.B.,Zhou, H.,Katzenellenbogen, J.A.,Katzenellenbogen, B.S.,Kim, Y.,Joachmiak, A.,Greene, G.L. (deposition date: 2007-06-14, release date: 2008-03-18, Last modification date: 2024-02-21)
Primary citation	Nettles, K.W.,Bruning, J.B.,Gil, G.,Nowak, J.,Sharma, S.K.,Hahm, J.B.,Kulp, K.,Hochberg, R.B.,Zhou, H.,Katzenellenbogen, J.A.,Katzenellenbogen, B.S.,Kim, Y.,Joachmiak, A.,Greene, G.L. NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses Nat.Chem.Biol., 4:241-247, 2008 Cited by PubMed: 18344977 DOI: 10.1038/nchembio.76 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation