2OCF

Human estrogen receptor alpha ligand-binding domain in complex with estradiol and the E2#23 FN3 monobody

Summary for 2OCF

• Entry DOI: 10.2210/pdb2ocf/pdb
• Descriptor: Estrogen receptor, Fibronectin, ESTRADIOL, ... (4 entities in total)
• Functional Keywords: estrogen receptor, lbd, monobody, estradiol, hormone-growth factor complex, hormone/growth factor
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372; Secreted, extracellular space, extracellular matrix: P02751
• Total number of polymer chains: 2
• Total formula weight: 47197.40

Authors

Rajan, S.S.,Kuruvilla, S.M.,Sharma, S.K.,Kim, Y.,Huang, J.,Koide, A.,Koide, S.,Joachimiak, A.,Greene, G.L. (deposition date: 2006-12-20, release date: 2007-11-06, Last modification date: 2023-08-30)

• Primary citation: Koide, A.,Abbatiello, S.,Rothgery, L.,Koide, S.; Probing protein conformational changes in living cells by using designer binding proteins: application to the estrogen receptor.; Proc.Natl.Acad.Sci.USA, 99:1253-1258, 2002; PubMed: 11818562; DOI: 10.1073/pnas.032665299

Experimental method

X-RAY DIFFRACTION (2.95 Å)