2O8C
human MutSalpha (MSH2/MSH6) bound to ADP and an O6-methyl-guanine T mispair
Summary for 2O8C
Entry DOI | 10.2210/pdb2o8c/pdb |
Related | 2O8B 2O8D 2O8E 2O8F |
Descriptor | 5'-D(*GP*AP*AP*CP*CP*GP*CP*(6OG)P*CP*GP*CP*TP*AP*GP*G)-3', 5'-D(*CP*CP*TP*AP*GP*CP*GP*TP*GP*CP*GP*GP*TP*TP*C)-3', DNA mismatch repair protein Msh2, ... (7 entities in total) |
Functional Keywords | dna mismatch repair, dna damage response, protein-dna complex, dna mispair, cancer, o6-methyl-guanine, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus (Potential): P43246 Nucleus: P52701 |
Total number of polymer chains | 4 |
Total formula weight | 231032.54 |
Authors | Warren, J.J.,Pohlhaus, T.J.,Changela, A.,Modrich, P.L.,Beese, L.S. (deposition date: 2006-12-12, release date: 2007-06-05, Last modification date: 2023-08-30) |
Primary citation | Warren, J.J.,Pohlhaus, T.J.,Changela, A.,Iyer, R.R.,Modrich, P.L.,Beese, L.S. Structure of the Human MutSalpha DNA Lesion Recognition Complex. Mol.Cell, 26:579-592, 2007 Cited by PubMed: 17531815DOI: 10.1016/j.molcel.2007.04.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.37 Å) |
Structure validation
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