2O2U

Crystal structure of human JNK3 complexed with N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide

Summary for 2O2U

• Entry DOI: 10.2210/pdb2o2u/pdb
• Related: 2O0U
• Descriptor: Mitogen-activated protein kinase 10, N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide (3 entities in total)
• Functional Keywords: kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P53779
• Total number of polymer chains: 1
• Total formula weight: 42360.03

Authors

Somers, D.,Rowland, P. (deposition date: 2006-11-30, release date: 2007-02-27, Last modification date: 2023-12-27)

• Primary citation: Angell, R.M.,Atkinson, F.L.,Brown, M.J.,Chuang, T.T.,Christopher, J.A.,Cichy-Knight, M.,Dunn, A.K.,Hightower, K.E.,Malkakorpi, S.,Musgrave, J.R.,Neu, M.,Rowland, P.,Shea, R.L.,Smith, J.L.,Somers, D.O.,Thomas, S.A.,Thompson, G.,Wang, R.; N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3.; Bioorg.Med.Chem.Lett., 17:1296-1301, 2007; PubMed: 17194588; DOI: 10.1016/j.bmcl.2006.12.003

Experimental method

X-RAY DIFFRACTION (2.45 Å)