2MB3
Solution structure of an intramolecular (3+1) human telomeric G-quadruplex bound to a telomestatin derivative
Summary for 2MB3
Entry DOI | 10.2210/pdb2mb3/pdb |
NMR Information | BMRB: 19387 |
Descriptor | DNA_(5'-D(*TP*TP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*A)-3'), (12S,27S)-12,27-bis(4-aminobutyl)-4,30-dimethyl-3,7,14,18,22,29-hexaoxa-11,26,31,32,33,34,35,36-octaazaheptacyclo[26.2. 1.1~2,5~.1~6,9~.1~13,16~.1~17,20~.1~21,24~]hexatriaconta-1(30),2(36),4,6(35),8,13(34),15,17(33),19,21(32),23,28(31)-dode caene-10,25-dione (2 entities in total) |
Functional Keywords | intramolecular g-quadruplex, human telomere, anticancer targets, macrocyclic hexaoxazole, telomestatin derivative, dna-dna inhibitor complex, dna/dna inhibitor |
Total number of polymer chains | 1 |
Total formula weight | 8278.56 |
Authors | Chung, W.J.,Heddi, B.,Tera, M.,Iida, K.,Nagasawa, K.,Phan, A.T. (deposition date: 2013-07-24, release date: 2013-08-28, Last modification date: 2024-05-15) |
Primary citation | Chung, W.J.,Heddi, B.,Tera, M.,Iida, K.,Nagasawa, K.,Phan, A.T. Solution structure of an intramolecular (3 + 1) human telomeric g-quadruplex bound to a telomestatin derivative. J.Am.Chem.Soc., 135:13495-13501, 2013 Cited by PubMed: 23909929DOI: 10.1021/ja405843r PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report