2LY4
HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail
Summary for 2LY4
Entry DOI | 10.2210/pdb2ly4/pdb |
NMR Information | BMRB: 18709 |
Descriptor | High mobility group protein B1, Cellular tumor antigen p53 (2 entities in total) |
Functional Keywords | hmg, p53, tad, nuclear protein-antitumour protein complex, nuclear protein/antitumour protein |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P09429 Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 2 |
Total formula weight | 19686.19 |
Authors | Rowell, J.P.,Simpson, K.L.,Stott, K.,Watson, M.,Thomas, J.O. (deposition date: 2012-09-12, release date: 2012-10-31, Last modification date: 2024-05-01) |
Primary citation | Rowell, J.P.,Simpson, K.L.,Stott, K.,Watson, M.,Thomas, J.O. HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail. Structure, 20:2014-2024, 2012 Cited by PubMed: 23063560DOI: 10.1016/j.str.2012.09.004 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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