2LB0

Structure of the first WW domain of human Smurf1 in complex with a di-phosphorylated human Smad1 derived peptide

Summary for 2LB0

Entry DOI	10.2210/pdb2lb0/pdb
Related	2LAW 2LAX 2LAY 2LAZ 2LB1 2LB2 2LB3
NMR Information	BMRB: 17542
Descriptor	E3 ubiquitin-protein ligase SMURF1, Mothers against decapentaplegic homolog 1 (2 entities in total)
Functional Keywords	smurf, smad, cdk, signal transduction, signaling protein-transcription complex, signaling protein/transcription
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: Q9HCE7 Q15797
Total number of polymer chains	2
Total formula weight	5319.53
Authors	Macias, M.J.,Aragon, E.,Goerner, N.,Zaromytidou, A.,Xi, Q.,Escobedo, A.,Massague, J. (deposition date: 2011-03-22, release date: 2011-07-06, Last modification date: 2011-07-13)
Primary citation	Aragon, E.,Goerner, N.,Zaromytidou, A.I.,Xi, Q.,Escobedo, A.,Massague, J.,Macias, M.J. A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev., 25:1275-1288, 2011 Cited by PubMed: 21685363 DOI: 10.1101/gad.2060811 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation