2K8P
Characterisation of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation
Summary for 2K8P
Entry DOI | 10.2210/pdb2k8p/pdb |
Descriptor | Sclerostin (1 entity in total) |
Functional Keywords | wnt signalling pathway, bone formation, alternative splicing, glycoprotein, secreted, signaling protein |
Biological source | Homo sapiens (man) |
Cellular location | Secreted (Potential): Q9BQB4 |
Total number of polymer chains | 1 |
Total formula weight | 21432.33 |
Authors | Veverka, V.,Henry, A.J.,Slocombe, P.M.,Ventom, A.,Mulloy, B.,Muskett, F.W.,Muzylak, M.,Greenslade, K.,Moore, A.,Zhang, L.,Gong, J.,Qian, X.,Paszty, C.,Taylor, R.J.,Robinson, M.K.,Carr, M.D. (deposition date: 2008-09-18, release date: 2009-02-17, Last modification date: 2022-03-16) |
Primary citation | Veverka, V.,Henry, A.J.,Slocombe, P.M.,Ventom, A.,Mulloy, B.,Muskett, F.W.,Muzylak, M.,Greenslade, K.,Moore, A.,Zhang, L.,Gong, J.,Qian, X.,Paszty, C.,Taylor, R.J.,Robinson, M.K.,Carr, M.D. Characterization of the Structural Features and Interactions of Sclerostin: Molecular insight into a key regulator of Wnt-mediated bone formation J.Biol.Chem., 284:10890-10900, 2009 Cited by PubMed: 19208630DOI: 10.1074/jbc.M807994200 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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