2H8R
Hepatocyte Nuclear Factor 1b bound to DNA: MODY5 Gene Product
Summary for 2H8R
Entry DOI | 10.2210/pdb2h8r/pdb |
Descriptor | 5'-D(*CP*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*TP*CP*AP*CP*CP*AP*G)-3', 5'-D(*GP*CP*TP*GP*GP*TP*GP*AP*AP*TP*TP*AP*TP*TP*AP*AP*CP*CP*AP*A)-3', Hepatocyte nuclear factor 1-beta, ... (4 entities in total) |
Functional Keywords | trasncription factor, pou, homeo, protein-dna, human disease, transcription activator-dna complex, transcription activator/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P35680 |
Total number of polymer chains | 4 |
Total formula weight | 63688.69 |
Authors | |
Primary citation | Lu, P.,Rha, G.B.,Chi, Y.I. Structural basis of disease-causing mutations in hepatocyte nuclear factor 1beta. Biochemistry, 46:12071-12080, 2007 Cited by PubMed: 17924661DOI: 10.1021/bi7010527 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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