Hepatocyte Nuclear Factor 1b bound to DNA: MODY5 Gene Product

Summary for 2H8R

DescriptorHepatocyte nuclear factor 1-beta/DNA Complex
Functional Keywordstrasncription factor, pou, homeo, protein-dna, human disease, transcription activator-dna complex, transcription activator/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus P35680
Total number of polymer chains4
Total molecular weight63689.22
Lu, P.,Rha, G.B.,Chi, Y.I. (deposition date: 2006-06-07, release date: 2007-06-19, modification date: 2009-02-24)
Primary citation
Lu, P.,Rha, G.B.,Chi, Y.I.
Structural basis of disease-causing mutations in hepatocyte nuclear factor 1beta.
Biochemistry, 46:12071-12080, 2007
PubMed: 17924661
DOI: 10.1021/bi7010527
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2667510.8%21.8%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2h8r
no rotation
Molmil generated image of 2h8r
rotated about x axis by 90°
Molmil generated image of 2h8r
rotated about y axis by 90°
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