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2GTK

Structure-based Design of Indole Propionic Acids as Novel PPARag CO-Agonists

Summary for 2GTK
Entry DOI10.2210/pdb2gtk/pdb
DescriptorPeroxisome proliferator-activated receptor gamma, Decamer from Nuclear receptor coactivator 1, (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID, ... (4 entities in total)
Functional Keywordsnuclear receptor, transcription regulator
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus: P37231 Q15788
Total number of polymer chains2
Total formula weight32591.31
Authors
Kuhn, B.,Hilpert, H.,Benz, J.,Binggeli, A.,Grether, U.,Humm, R.,Maerki, H.-P.,Meyer, M.,Mohr, P. (deposition date: 2006-04-28, release date: 2006-09-26, Last modification date: 2024-02-14)
Primary citationKuhn, B.,Hilpert, H.,Benz, J.,Binggeli, A.,Grether, U.,Humm, R.,Meyer, M.,Mohr, P.
Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists
Bioorg.Med.Chem.Lett., 16:4016-4020, 2006
Cited by
PubMed: 16737814
DOI: 10.1016/j.bmcl.2006.05.007
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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