2GIU

Human estrogen receptor beta ligand-binding domain in complex with compound 45

Summary for 2GIU

• Entry DOI: 10.2210/pdb2giu/pdb
• Descriptor: Estrogen receptor beta, (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one (3 entities in total)
• Functional Keywords: nuclear receptor, transcription factor, er-beta, agonist, transcription regulator
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : Q92731
• Total number of polymer chains: 1
• Total formula weight: 27557.53

Authors

Fitzgerald, P.M.D.,Sharma, N. (deposition date: 2006-03-29, release date: 2006-10-10, Last modification date: 2024-04-03)

• Primary citation: Wilkening, R.R.,Ratcliffe, R.W.,Tynebor, E.C.,Wildonger, K.J.,Fried, A.K.,Hammond, M.L.,Mosley, R.T.,Fitzgerald, P.M.D.,Sharma, N.,McKeever, B.M.,Nilsson, S.,Carlquist, M.,Thorsell, A.,Locco, L.,Katz, R.,Frisch, K.,Birzin, E.T.,Wilkinson, H.A.,Mitra, S.,Cai, S.,Hayes, E.C.,Schaeffer, J.M.,Rohrer, S.P.; The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands.; Bioorg.Med.Chem.Lett., 16:3489-3494, 2006; PubMed: 16632357; DOI: 10.1016/j.bmcl.2006.03.098

Experimental method

X-RAY DIFFRACTION (2.2 Å)