2FSM

mitogen activated protein kinase p38alpha (D176A+F327S) activating mutant form-B

Summary for 2FSM

Entry DOI	10.2210/pdb2fsm/pdb
Related	2FSL 2FSO 2FST
Descriptor	Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside (3 entities in total)
Functional Keywords	mitogen activated protein kinase, p38, active mutants, lipids, map kinase insertion, autophosphorylation, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	42431.42
Authors	Diskin, R.,Livnah, O. (deposition date: 2006-01-23, release date: 2006-12-05, Last modification date: 2021-11-10)
Primary citation	Diskin, R.,Lebendiker, M.,Engelberg, D.,Livnah, O. Structures of p38alpha Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation J.Mol.Biol., 365:66-76, 2007 Cited by PubMed: 17059827 DOI: 10.1016/j.jmb.2006.08.043 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation