2F1X
Crystal structure of the TRAF-like domain of HAUSP/USP7 bound to a p53 peptide
Summary for 2F1X
Entry DOI | 10.2210/pdb2f1x/pdb |
Related | 2F1W |
Descriptor | HAUSP/USP7 (2 entities in total) |
Functional Keywords | traf-like domain, p53 recognition, peptide binding, hausp, usp7, ubp, substrate recognition, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 2 |
Total formula weight | 37413.37 |
Authors | Hu, M.,Gu, L.,Jeffrey, P.D.,Shi, Y. (deposition date: 2005-11-15, release date: 2006-02-07, Last modification date: 2023-08-23) |
Primary citation | Hu, M.,Gu, L.,Li, M.,Jeffrey, P.D.,Gu, W.,Shi, Y. Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway. Plos Biol., 4:e27-e27, 2006 Cited by PubMed: 16402859DOI: 10.1371/journal.pbio.0040027 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report