2A0C
Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor
Summary for 2A0C
Entry DOI | 10.2210/pdb2a0c/pdb |
Descriptor | Cell division protein kinase 2, 2-{[(2-{[(1R)-1-(HYDROXYMETHYL)PROPYL]AMINO}-9-ISOPROPYL-9H-PURIN-6-YL)AMINO]METHYL}PHENOL (3 entities in total) |
Functional Keywords | protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase, serine/threonine-protein kinase, atp-binding |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 34346.94 |
Authors | Krystof, V.,McNae, I.W.,Walkinshaw, M.D.,Fischer, P.M.,Muller, P.,Vojtesek, B.,Orsag, M.,Havlicek, L.,Strnad, M. (deposition date: 2005-06-16, release date: 2006-01-24, Last modification date: 2024-03-13) |
Primary citation | Krystof, V.,McNae, I.W.,Walkinshaw, M.D.,Fischer, P.M.,Muller, P.,Vojtesek, B.,Orsag, M.,Havlicek, L.,Strnad, M. Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor Cell.Mol.Life Sci., 62:1763-1771, 2005 Cited by PubMed: 16003486DOI: 10.1007/s00018-005-5185-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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