2XRG
Crystal structure of Autotaxin (ENPP2) in complex with the HA155 boronic acid inhibitor
Summary for 2XRG
Entry DOI | 10.2210/pdb2xrg/pdb |
Related | 2XR9 |
Descriptor | ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, {4-[(4-{(Z)-[3-(4-FLUOROBENZYL)-2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE]METHYL}PHENOXY)METHYL]PHENYL}(TRIHYDROXY)BORATE(1-), ... (7 entities in total) |
Functional Keywords | hydrolase, lysophosphatidic acid, lpa, lysophosphatidylcholine, lpc, somatomedin, metastasis, neuropathic pain, vascular development, neural development |
Biological source | RATTUS NORVEGICUS (NORWAY RAT) |
Total number of polymer chains | 1 |
Total formula weight | 100741.46 |
Authors | Hausmann, J.,Albers, H.M.H.G.,Perrakis, A. (deposition date: 2010-09-14, release date: 2011-01-19, Last modification date: 2023-12-20) |
Primary citation | Hausmann, J.,Kamtekar, S.,Christodoulou, E.,Day, J.E.,Wu, T.,Fulkerson, Z.,Albers, H.M.H.G.,Van Meeteren, L.A.,Houben, A.J.,Van Zeijl, L.,Jansen, S.,Andries, M.,Hall, T.,Pegg, L.E.,Benson, T.E.,Kasiem, M.,Harlos, K.,Kooi, C.W.,Smyth, S.S.,Ovaa, H.,Bollen, M.,Morris, A.J.,Moolenaar, W.H.,Perrakis, A. Structural Basis of Substrate Discrimination and Integrin Binding by Autotaxin. Nat.Struct.Mol.Biol., 18:198-, 2011 Cited by PubMed: 21240271DOI: 10.1038/NSMB.1980 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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