1XQH

Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH

Summary for 1XQH

Entry DOI	10.2210/pdb1xqh/pdb
Related	1h3i 1o9s
Descriptor	Histone-lysine N-methyltransferase, H3 lysine-4 specific, 9-mer peptide from tumor protein p53, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
Functional Keywords	set9-p53 complex, set-domain, lysine methylation, transferase
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: Q8WTS6 Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
Total number of polymer chains	4
Total formula weight	61726.69
Authors	Chuikov, S.,Kurash, J.K.,Wilson, J.R.,Xiao, B.,Justin, N.,Ivanov, G.S.,McKinney, K.,Tempst, P.,Prives, C.,Gamblin, S.J.,Barlev, N.A.,Reinberg, D. (deposition date: 2004-10-12, release date: 2004-11-23, Last modification date: 2023-10-25)
Primary citation	Chuikov, S.,Kurash, J.K.,Wilson, J.R.,Xiao, B.,Justin, N.,Ivanov, G.S.,McKinney, K.,Tempst, P.,Prives, C.,Gamblin, S.J.,Barlev, N.A.,Reinberg, D. Regulation of p53 activity through lysine methylation Nature, 432:353-360, 2004 Cited by PubMed: 15525938 DOI: 10.1038/nature03117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation