1MW4
Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139
Summary for 1MW4
| Entry DOI | 10.2210/pdb1mw4/pdb |
| Descriptor | Growth factor receptor-bound protein 7, Receptor protein-tyrosine kinase erbB-2 (2 entities in total) |
| Functional Keywords | sh2 domain in complex with a ligand, hormone-growth factor-transferase complex, hormone/growth factor/transferase |
| Biological source | Homo sapiens (human) More |
| Cellular location | Cytoplasm: Q14451 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626 |
| Total number of polymer chains | 2 |
| Total formula weight | 14956.92 |
| Authors | Ivancic, M.,Lyons, B.A. (deposition date: 2002-09-27, release date: 2003-09-09, Last modification date: 2012-05-02) |
| Primary citation | Ivancic, M.,Daly, R.J.,Lyons, B.A. Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2 J.BIOMOL.NMR, 27:205-219, 2003 Cited by PubMed: 12975581DOI: 10.1023/A:1025498409113 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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