1BRC
RELOCATING A NEGATIVE CHARGE IN THE BINDING POCKET OF TRYPSIN
Summary for 1BRC
| Entry DOI | 10.2210/pdb1brc/pdb |
| Descriptor | TRYPSIN, AMYLOID BETA-PROTEIN PRECURSOR INHIBITOR DOMAIN (APPI) (3 entities in total) |
| Functional Keywords | proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Rattus norvegicus (Norway rat) |
| Cellular location | Secreted, extracellular space: P00763 Membrane; Single-pass type I membrane protein: P05067 |
| Total number of polymer chains | 2 |
| Total formula weight | 30076.83 |
| Authors | Perona, J.J.,Fletterick, R.J. (deposition date: 1992-12-17, release date: 1994-05-31, Last modification date: 2017-11-29) |
| Primary citation | Perona, J.J.,Tsu, C.A.,McGrath, M.E.,Craik, C.S.,Fletterick, R.J. Relocating a negative charge in the binding pocket of trypsin. J.Mol.Biol., 230:934-949, 1993 Cited by PubMed: 8478942DOI: 10.1006/jmbi.1993.1211 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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