6B0A

Crystal structure of Pfs25 in complex with the transmission blocking antibody 1269

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	H	1269 antibody, heavy chain	polymer	228	24012.6	1		Homo sapiens (Human)
2	L	1269 antibody, light chain	polymer	212	23179.7	1		Homo sapiens (Human)
3	A	25 kDa ookinete surface antigen	polymer	183	20104.2	1	UniProt (P13829) Pfam (PF06247) In PDB	Plasmodium falciparum	Pfs25
4	L, A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5		water	water		18.0	15	Chemie (HOH)

Sequence modifications

A: 1 - 172 (UniProt: P13829)

PDB	External Database	Details
Thr -1	-	expression tag
Gly 0	-	expression tag
Gln 91	Asn 112	engineered mutation
Gln 144	Asn 165	engineered mutation
Gln 166	Asn 187	engineered mutation
Gly 173	-	expression tag
Thr 174	-	expression tag
Lys 175	-	expression tag
His 176	-	expression tag
His 177	-	expression tag
His 178	-	expression tag
His 179	-	expression tag
His 180	-	expression tag
His 181	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	67296.4
Non-Polymers*	Number of molecules	2
	Total formula weight	184.2
All*	Total formula weight	67480.6

*Water molecules are not included.