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8EPT	UBE3A isoform 2 AZUL domain Descriptor: Ubiquitin-protein ligase E3A, ZINC ION Authors: Bregnard, T.A, Bezsonova, I. Deposit date: 2022-10-06 Release date: 2023-07-05 Method: SOLUTION NMR Cite: Differences in structure, dynamics and Zn-coordination between isoforms of human ubiquitin ligase UBE3A To Be Published
8ENP	UBE3A isoform 3 AZUL Descriptor: Isoform III of Ubiquitin-protein ligase E3A, ZINC ION Authors: Bregnard, T.A, Bezsonova, I. Deposit date: 2022-09-30 Release date: 2023-10-18 Method: SOLUTION NMR Cite: Differences in structure, dynamics and Zn-coordination between isoforms of human ubiquitin ligase UBE3A To Be Published
2KR1	Solution NMR structure of zinc binding N-terminal domain of ubiquitin-protein ligase E3A from Homo Sapiens. Northeast Structural Genomics Consortium (NESG) target HR3662 Descriptor: Ubiquitin protein ligase E3A, ZINC ION Authors: Lemak, A, Yee, A, Fares, C, Semesi, A, Xiao, R, Montelione, G, Dhe-Paganon, S, Arrowsmith, C, Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC) Deposit date: 2009-11-27 Release date: 2009-12-22 Last modified: 2020-02-26 Method: SOLUTION NMR Cite: Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A. J.Biomol.Nmr, 51, 2011
6U19	Solution Structure of the RAZUL domain from 26S proteasome subunit hRpn10/S5a complexed with the AZUL domain from E3 ligase E6AP/UBE3A Descriptor: 26S proteasome non-ATPase regulatory subunit 4, Ubiquitin-protein ligase E3A, ZINC ION Authors: Chen, X, Walters, K.J. Deposit date: 2019-08-15 Release date: 2020-03-18 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10. Nat Commun, 11, 2020
8GCR	HPV16 E6-E6AP-p53 complex Descriptor: Cellular tumor antigen p53, Maltose/maltodextrin-binding periplasmic protein,Protein E6, Ubiquitin-protein ligase E3A, ... Authors: Bratkowski, M.A, Wang, J.C.K, Hao, Q, Nile, A.H. Deposit date: 2023-03-02 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: Structure of the p53 degradation complex from HPV16. Nat Commun, 15, 2024
6WJD	SA-like state of human 26S Proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin ligase E6AP/UBE3A Descriptor: 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... Authors: Chen, X, Walters, K.J. Deposit date: 2020-04-13 Release date: 2020-08-05 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: Cryo-EM Reveals Unanchored M1-Ubiquitin Chain Binding at hRpn11 of the 26S Proteasome. Structure, 28, 2020
6TGK	Domain swapped E6AP C-lobe dimer Descriptor: ACETATE ION, CALCIUM ION, Ubiquitin-protein ligase E3A Authors: Ries, L.K, Feiler, C, Lowe, L.D, Liess, A.K.L, Lorenz, S. Deposit date: 2019-11-16 Release date: 2020-02-26 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Crystal structure of the catalytic C-lobe of the HECT-type ubiquitin ligase E6AP. Protein Sci., 29, 2020
6WJN	SD-like state of human 26S Proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin ligase E6AP/UBE3A Descriptor: 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... Authors: Chen, X, Walters, K.J. Deposit date: 2020-04-14 Release date: 2020-08-05 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (5.7 Å) Cite: Cryo-EM Reveals Unanchored M1-Ubiquitin Chain Binding at hRpn11 of the 26S Proteasome. Structure, 28, 2020
4GIZ	Crystal structure of full-length human papillomavirus oncoprotein E6 in complex with LXXLL peptide of ubiquitin ligase E6AP at 2.55 A resolution Descriptor: Maltose-binding periplasmic protein, UBIQUITIN LIGASE EA6P: chimeric protein, Protein E6, ... Authors: McEwen, A.G, Zanier, K, Charbonnier, S, Poussin, P, Cura, V, Vande Pol, S, Trave, G, Cavarelli, J. Deposit date: 2012-08-09 Release date: 2013-01-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins. Science, 339, 2013
7QPB	Catalytic C-lobe of the HECT-type ubiquitin ligase E6AP in complex with a hybrid foldamer-peptide macrocycle Descriptor: Isoform I of Ubiquitin-protein ligase E3A, hybrid foldamer-peptide macrocycle Authors: Dengler, S, Howard, R.T, Morozov, V, Tsiamantas, C, Douat, C, Suga, H, Huc, I. Deposit date: 2022-01-03 Release date: 2023-09-27 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.342 Å) Cite: Display Selection of a Hybrid Foldamer-Peptide Macrocycle. Angew.Chem.Int.Ed.Engl., 62, 2023
8R1G	Dimeric ternary structure of E6AP-E6-p53 Descriptor: Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... Authors: Sandate, C.R, Chakrabory, D, Kater, L, Kempf, G, Thoma, N.H. Deposit date: 2023-11-01 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (3.99 Å) Cite: Monomeric E6AP-E6-p53 ternary complex To Be Published
8R1F	Monomeric E6AP-E6-p53 ternary complex Descriptor: Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... Authors: Sandate, C.R, Chakraborty, D, Kater, L, Kempf, G, Thoma, N.H. Deposit date: 2023-11-01 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (3.67 Å) Cite: Monomeric E6AP-E6-p53 ternary complex To Be Published
6SJV	Structure of HPV18 E6 oncoprotein in complex with mutant E6AP LxxLL motif Descriptor: Maltodextrin-binding protein,Protein E6,Ubiquitin-protein ligase E3A, ZINC ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose Authors: Suarez, I.P, Cousido-Siah, A, Bonhoure, A, Kostmann, C, Mitschler, A, Podjarny, A, Trave, G. Deposit date: 2019-08-14 Release date: 2019-09-04 Last modified: 2022-03-30 Method: X-RAY DIFFRACTION (2.029 Å) Cite: Cellular target recognition by HPV18 and HPV49 oncoproteins To be published
6SLM	Crystal structure of full-length HPV31 E6 oncoprotein in complex with LXXLL peptide of ubiquitin ligase E6AP Descriptor: GLYCEROL, Maltose/maltodextrin-binding periplasmic protein,Protein E6,Ubiquitin-protein ligase E3A, ZINC ION, ... Authors: Conrady, M, Gogl, G, Cousido-Siah, A, Mitschler, A, Trave, G, Simon, C. Deposit date: 2019-08-20 Release date: 2020-09-09 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of High-Risk Papillomavirus 31 E6 Oncogenic Protein and Characterization of E6/E6AP/p53 Complex Formation. J.Virol., 95, 2020
1C4Z	STRUCTURE OF AN E6AP-UBCH7 COMPLEX: INSIGHTS INTO THE UBIQUITINATION PATHWAY Descriptor: UBIQUITIN CONJUGATING ENZYME E2, UBIQUITIN-PROTEIN LIGASE E3A Authors: Huang, L, Kinnucan, E, Wang, G, Beaudenon, S, Howley, P.M, Huibregtse, J.M, Pavletich, N.P. Deposit date: 1999-10-14 Release date: 1999-11-17 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. Science, 286, 1999
1D5F	STRUCTURE OF E6AP: INSIGHTS INTO UBIQUITINATION PATHWAY Descriptor: E6AP HECT CATALYTIC DOMAIN, E3 LIGASE Authors: Huang, L, Kinnucan, E, Wang, G, Beaudenon, S, Howley, P.M, Huibregtse, J.M, Pavletich, N.P. Deposit date: 1999-10-07 Release date: 1999-11-17 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. Science, 286, 1999
1EQX	SOLUTION STRUCTURE DETERMINATION AND MUTATIONAL ANALYSIS OF THE PAPILLOMAVIRUS E6-INTERACTING PEPTIDE OF E6AP Descriptor: PAPILLOMAVIRUS E6-ASSOCIATED PROTEIN Authors: Be, X, Hong, Y, Androphy, E.J, Chen, J.J, Baleja, J.D. Deposit date: 2000-04-06 Release date: 2001-02-28 Last modified: 2022-02-16 Method: SOLUTION NMR Cite: Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6AP. Biochemistry, 40, 2001
7Q41	Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of ubiquitin-protein ligase E3A (E6AP) Descriptor: CITRIC ACID, E3 ubiquitin-protein ligase HERC2, Ubiquitin-protein ligase E3A (E6AP) peptide Authors: Demenge, A, Howard, E, Cousido-Siah, A, Mitschler, A, Podjarny, A, McEwen, A.G, Trave, G. Deposit date: 2021-10-29 Release date: 2022-11-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3.01478052 Å) Cite: Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of ubiquitin-protein ligase E3A (E6AP) To Be Published