3H8H
 
 | | Structure of the C-terminal domain of human RNF2/RING1B; | | Descriptor: | CHLORIDE ION, E3 ubiquitin-protein ligase RING2, GLYCEROL, ... | | Authors: | Walker, J.R, Bezsonova, I, Bacik, J, Duan, S, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2009-04-29 | | Release date: | 2009-06-23 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins.
Biochemistry, 48, 2009
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7ND1
 | | First-in-class small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) RING domain | | Descriptor: | 3-(2-chlorophenyl)-4-ethyl-5-(1~{H}-indol-4-yl)-1~{H}-pyrrole-2-carboxylic acid, E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1, ... | | Authors: | Cierpicki, T, Lund, G, Jaremko, L. | | Deposit date: | 2021-01-29 | | Release date: | 2021-06-16 | | Last modified: | 2021-07-07 | | Method: | SOLUTION NMR | | Cite: | Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
Nat.Chem.Biol., 17, 2021
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8PP7
 | | human RYBP-PRC1 bound to mononucleosome | | Descriptor: | DNA (215-mer), E3 ubiquitin-protein ligase RING2, Histone H2A, ... | | Authors: | Ciapponi, M, Benda, C, Mueller, J. | | Deposit date: | 2023-07-06 | | Release date: | 2024-03-27 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (2.91 Å) | | Cite: | Structural basis of the histone ubiquitination read-write mechanism of RYBP-PRC1.
Nat.Struct.Mol.Biol., 2024
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3RPG
 | | Bmi1/Ring1b-UbcH5c complex structure | | Descriptor: | E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1, Ubiquitin-conjugating enzyme E2 D3, ... | | Authors: | Bentley, M.L, Dong, K.C, Cochran, A.G. | | Deposit date: | 2011-04-26 | | Release date: | 2011-08-17 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.6485 Å) | | Cite: | Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.
Embo J., 30, 2011
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4R8P
 | | Crystal structure of the Ring1B/Bmi1/UbcH5c PRC1 ubiquitylation module bound to the nucleosome core particle | | Descriptor: | DNA (147-mer), E3 ubiquitin-protein ligase RING2, Ubiquitin-conjugating enzyme E2 D3, ... | | Authors: | McGinty, R.K, Henrici, R.C, Tan, S. | | Deposit date: | 2014-09-02 | | Release date: | 2014-11-05 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.2846 Å) | | Cite: | Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome.
Nature, 514, 2014
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4S3O
 | | PCGF5-RING1B-UbcH5c complex | | Descriptor: | E3 ubiquitin-protein ligase RING2, Polycomb group RING finger protein 5, Ubiquitin-conjugating enzyme E2 D3, ... | | Authors: | Taherbhoy, A.M, Cochran, A.G. | | Deposit date: | 2015-03-23 | | Release date: | 2015-07-15 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase.
Nat Commun, 6, 2015
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6WI7
 | | RING1B-BMI1 fusion in closed conformation | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1 chimera, ... | | Authors: | Cho, H.J, Cierpicki, T. | | Deposit date: | 2020-04-08 | | Release date: | 2021-04-14 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (1.702 Å) | | Cite: | Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
Nat.Chem.Biol., 17, 2021
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6WI8
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3GS2
 | | Ring1B C-terminal domain/Cbx7 Cbox Complex | | Descriptor: | Chromobox protein homolog 7, E3 ubiquitin-protein ligase RING2, SULFATE ION, ... | | Authors: | Wang, R, Taylor, A.B, Kim, C.A. | | Deposit date: | 2009-03-26 | | Release date: | 2010-08-25 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.699 Å) | | Cite: | Polycomb Group Targeting through Different Binding Partners of RING1B C-Terminal Domain.
Structure, 18, 2010
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3IXS
 | | Ring1B C-terminal domain/RYBP C-terminal domain Complex | | Descriptor: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, E3 ubiquitin-protein ligase RING2, ... | | Authors: | Wang, R, Taylor, A.B, Kim, C.A. | | Deposit date: | 2009-09-04 | | Release date: | 2010-08-25 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Polycomb Group Targeting through Different Binding Partners of RING1B C-Terminal Domain.
Structure, 18, 2010
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