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1U6D
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1u6d
CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KEAP1
Descriptor:kelch-like ECH-associated protein 1
Authors:Li, X., Zhang, D., Hannink, M., Beamer, L.J.
Deposit date:2004-07-29
Release date:2004-10-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of the kelch domain of human keap1
J.Biol.Chem., 279, 2004
1X2J
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1x2j
STRUCTURAL BASIS FOR THE DEFECTS OF HUMAN LUNG CANCER SOMATIC MUTATIONS IN THE REPRESSION ACTIVITY OF KEAP1 ON NRF2
Descriptor:Kelch-like ECH-associated protein 1
Authors:Padmanabhan, B., Tong, K.I., Nakamura, Y., Ohta, T., Scharlock, M., Kobayashi, A., Ohtsuji, M., Kang, M.-I., Yamamoto, M., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-04-25
Release date:2006-03-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer
Mol.Cell, 21, 2006
1X2R
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1x2r
STRUCTURAL BASIS FOR THE DEFECTS OF HUMAN LUNG CANCER SOMATIC MUTATIONS IN THE REPRESSION ACTIVITY OF KEAP1 ON NRF2
Descriptor:Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2 related factor 2
Authors:Padmanabhan, B., Tong, K.I., Nakamura, Y., Ohta, T., Scharlock, M., Kobayashi, A., Ohtsuji, M., Kang, M.-I., Yamamoto, M., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-04-26
Release date:2006-03-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer
Mol.Cell, 21, 2006
1ZGK
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1zgk
1.35 ANGSTROM STRUCTURE OF THE KELCH DOMAIN OF KEAP1
Descriptor:Kelch-like ECH-associated protein 1
Authors:Li, X., Bottoms, C.A., Hannink, M., Beamer, L.J.
Deposit date:2005-04-21
Release date:2005-10-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Conserved solvent and side-chain interactions in the 1.35 Angstrom structure of the Kelch domain of Keap1.
Acta Crystallogr.,Sect.D, 61, 2005
2DYH
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2dyh
CRYSTAL STRUCTURE OF THE KEAP1 PROTEIN IN COMPLEXED WITH THE N-TERMINAL REGION OF THE NRF2 TRANSCRIPTION FACTOR
Descriptor:Kelch-like ECH-associated protein 1, Nrf2/Neh2 peptide from Nuclear factor erythroid 2-related factor 2
Authors:Padmanabhan, B., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-09-14
Release date:2007-09-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response
Mol.Cell.Biol., 27, 2007
2FLU
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2flu
CRYSTAL STRUCTURE OF THE KELCH-NEH2 COMPLEX
Descriptor:Kelch-like ECH-associated protein 1, Nrf2
Authors:Li, X., Lo, J., Beamer, L., Hannink, M.
Deposit date:2006-01-06
Release date:2006-08-15
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.
Embo J., 25, 2006
2UVK
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2uvk
STRUCTURE OF YJHT
Descriptor:YJHT
Authors:Muller, A., Severi, E., Wilson, K.S., Thomas, G.H.
Deposit date:2007-03-12
Release date:2007-12-04
Modification date:2009-10-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Sialic Acid Mutarotation is Catalyzed by the Escherichia Coli Beta-Propeller Protein Yjht.
J.Biol.Chem., 283, 2008
2VPJ
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2vpj
CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KLHL12
Descriptor:KELCH-LIKE PROTEIN 12
Authors:Keates, T., Pike, A.C.W., Bullock, A.N., Salah, E., Filippakopoulos, P., Roos, A.K., von Delft, F., Savitsky, P., Weigelt, J., Edwards, A., Arrowsmith, C.H., Bountra, C., Knapp, S.
Deposit date:2008-02-29
Release date:2008-03-18
Modification date:2013-03-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
2WOZ
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2woz
THE NOVEL BETA-PROPELLER OF THE BTB-KELCH PROTEIN KRP1 PROVIDES THE BINDING SITE FOR LASP-1 THAT IS NECESSARY FOR PSEUDOPODIA EXTENSION
Descriptor:KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 10
Authors:Gray, C.H., Mcgarry, L.C., Spence, H.J., Riboldi-Tunnicliffe, A., Ozanne, B.W.
Deposit date:2009-07-31
Release date:2009-09-01
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Novel Beta-Propeller of the Btb-Kelch Protein Krp1 Provides the Binding Site for Lasp-1 that is Necessary for Pseudopodia Extension.
J.Biol.Chem., 284, 2009
2XN4
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2xn4
CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KLHL2 (MAYVEN)
Descriptor:KELCH-LIKE PROTEIN 2
Authors:Canning, P., Hozjan, V., Cooper, C.D.O., Ayinampudi, V., Vollmar, M., Pike, A.C.W., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N.
Deposit date:2010-07-30
Release date:2010-08-18
Modification date:2013-03-27
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
2Z32
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2z32
CRYSTAL STRUCTURE OF KEAP1 COMPLEXED WITH PROTHYMOSIN ALPHA
Descriptor:Kelch-like ECH-associated protein 1, Prothymosin alpha
Authors:Padmanabhan, B., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-05-31
Release date:2008-03-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of the complex of Keap1 with a prothymosin alpha peptide
Acta Crystallogr.,Sect.F, 64, 2008
3ADE
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3ade
CRYSTAL STRUCTURE OF KEAP1 IN COMPLEX WITH SEQUESTOSOME-1/P62
Descriptor:Kelch-like ECH-associated protein 1, Sequestosome-1
Authors:Kurokawa, H., Yamamoto, M.
Deposit date:2010-01-19
Release date:2010-03-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
Nat.Cell Biol., 12, 2010
3II7
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3ii7
CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KLHL7
Descriptor:Kelch-like protein 7
Authors:Chaikuad, A., Thangaratnarajah, C., Cooper, C.D.O., Ugochukwu, E., Muniz, J.R.C., Krojer, T., Sethi, R., Pike, A.C.W., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2009-07-31
Release date:2009-08-25
Modification date:2014-06-18
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.
J.Biol.Chem., 288, 2013
3VNG
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3vng
CRYSTAL STRUCTURE OF KEAP1 IN COMPLEX WITH SYNTHETIC SMALL MOLECULAR BASED ON A CO-CRYSTALLIZATION
Descriptor:Kelch-like ECH-associated protein 1
Authors:Kunishima, N., Tanaka, T., Satoh, M., Saburi, H.
Deposit date:2012-01-12
Release date:2013-01-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Keap1 in Complex with Synthetic Small Molecular based on a co-crystallization
To be Published
3VNH
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3vnh
CRYSTAL STRUCTURE OF KEAP1 SOAKED WITH SYNTHETIC SMALL MOLECULAR
Descriptor:Kelch-like ECH-associated protein 1
Authors:Kunishima, N., Tanaka, T., Satoh, M., Saburi, H.
Deposit date:2012-01-12
Release date:2013-01-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Keap1 Soaked with Synthetic Small Molecular
To be Published
3WDZ
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3wdz
CRYSTAL STRUCTURE OF KEAP1 IN COMPLEX WITH PHOSPHORYLATED P62
Descriptor:Kelch-like ECH-associated protein 1, Peptide from Sequestosome-1
Authors:Fukutomi, T., Takagi, K., Mizushima, T., Tanaka, K., Komatsu, M., Yamamoto, M.
Deposit date:2013-06-26
Release date:2013-09-04
Modification date:2013-12-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Mol.Cell, 51, 2013
3WN7
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3wn7
CRYSTAL STRUCTURE OF KEAP1 IN COMPLEX WITH THE N-TERMINAL REGION OF THE NRF2 TRANSCRIPTION FACTOR
Descriptor:Kelch-like ECH-associated protein 1, Peptide from Nuclear factor erythroid 2-related factor 2
Authors:Fukutomi, T., Takagi, K., Mizushima, T., Ohuchi, N., Yamamoto, M.
Deposit date:2013-12-05
Release date:2013-12-25
Modification date:2014-07-16
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1
Mol.Cell.Biol., 34, 2014
3ZGC
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3zgc
CRYSTAL STRUCTURE OF THE KEAP1-NEH2 COMPLEX
Descriptor:KELCH-LIKE ECH-ASSOCIATED PROTEIN 1, NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2
Authors:Hoerer, S., Reinert, D., Ostmann, K., Hoevels, Y., Nar, H.
Deposit date:2012-12-17
Release date:2013-06-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal-Contact Engineering to Obtain a Crystal Form of the Kelch Domain of Human Keap1 Suitable for Ligand-Soaking Experiments.
Acta Crystallogr.,Sect.F, 69, 2013
3ZGD
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3zgd
CRYSTAL STRUCTURE OF A KEAP1 MUTANT
Descriptor:KELCH-LIKE ECH-ASSOCIATED PROTEIN 1
Authors:Hoerer, S., Reinert, D., Ostmann, K., Hoevels, Y., Nar, H.
Deposit date:2012-12-17
Release date:2013-06-12
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystal-Contact Engineering to Obtain a Crystal Form of the Kelch Domain of Human Keap1 Suitable for Ligand-Soaking Experiments.
Acta Crystallogr.,Sect.F, 69, 2013
4ASC
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4asc
CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KBTBD5
Descriptor:KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 5
Authors:Canning, P., Ayinampudi, V., Krojer, T., Strain-Damerell, C., Raynor, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N., Structural Genomics Consortium, (SGC)
Deposit date:2012-04-30
Release date:2012-05-09
Modification date:2013-03-27
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
4CH9
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4ch9
CRYSTAL STRUCTURE OF THE HUMAN KLHL3 KELCH DOMAIN IN COMPLEX WITH A WNK4 PEPTIDE
Descriptor:KELCH-LIKE PROTEIN 3, SERINE/THREONINE-PROTEIN KINASE WNK4 (E.C.2.7.11.1)
Authors:Sorrell, F.J., Schumacher, F.R., Kurz, T., Alessi, D.R., Newman, J., Goubin, S., Chalk, R., Kopec, J., Tallant, C., Williams, E., Krojer, T., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2013-11-29
Release date:2014-01-08
Modification date:2014-05-28
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural and Biochemical Characterisation of the Klhl3-Wnk Kinase Interaction Important in Blood Pressure Regulation.
Biochem.J., 460, 2014
4CHB
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4chb
CRYSTAL STRUCTURE OF THE HUMAN KLHL2 KELCH DOMAIN IN COMPLEX WITH A WNK4 PEPTIDE
Descriptor:KELCH-LIKE PROTEIN 3, SERINE/THREONINE-PROTEIN KINASE WNK4 (E.C.2.7.11.1)
Authors:Sorrell, F.J., Schumacher, F.R., Kurz, T., Alessi, D.R., Newman, J., Cooper, C.D.O., Canning, P., Kopec, J., Williams, E., Krojer, T., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2013-11-29
Release date:2014-01-08
Modification date:2014-05-28
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structural and Biochemical Characterisation of the Klhl3-Wnk Kinase Interaction Important in Blood Pressure Regulation.
Biochem.J., 460, 2014
4IFL
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4ifl
CRYSTAL STRUCTURES OF APO KEAP1, KEAP1-PEPTIDE, AND KEAP1-COMPOUND COMPLEXES
Descriptor:CRYSTAL STRUCTURE OF THE KELCH-NEH2 COMPLEX
Authors:Pan, H., Lin, M., Yang, Y., Callaway, K., Baker, J., Diep, L., Yan, J., Tanaka, K., Zhu, Y.L., Konradi, A.W., Jobling, M., Tam, D., Ren, Z., Cheung, H., Bova, M., Riley, B.E., Yao, N., Artis, D.R.
Deposit date:2012-12-14
Release date:2013-12-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes
Acta Crystallogr.,Sect.D
4IFN
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4ifn
CRYSTAL STRUCTURES OF APO KEAP1, KEAP1-PEPTIDE, AND KEAP1-COMPOUND COMPLEXES
Descriptor:kelch-like ECH-associated protein 1
Authors:Pan, H., Lin, M., Yang, Y., Callaway, K., Baker, J., Diep, L., Yan, J., Tanaka, K., Zhu, Y.L., Konradi, A.W., Jobling, M., Tam, D., Ren, Z., Cheung, H., Bova, M., Riley, B.E., Yao, N., Artis, D.R.
Deposit date:2012-12-14
Release date:2013-12-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes
Acta Crystallogr.,Sect.D
4IN4
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4in4
CRYSTAL STRUCTURE OF CPD 15 BOUND TO KEAP1 KELCH DOMAIN
Descriptor:Kelch-like ECH-associated protein 1
Authors:Silvian, L., Marcotte, D.
Deposit date:2013-01-03
Release date:2013-05-15
Modification date:2013-07-03
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism.
Bioorg.Med.Chem., 21, 2013
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103354
entries available on 2014-09-17
00:00 UTC / 09:00 JST