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1AFW
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BU of 1afw by Molmil
THE 1.8 ANGSTROM CRYSTAL STRUCTURE OF THE DIMERIC PEROXISOMAL THIOLASE OF SACCHAROMYCES CEREVISIAE
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 3-KETOACETYL-COA THIOLASE
Authors:Mathieu, M, Wierenga, R.K.
Deposit date:1997-03-15
Release date:1997-06-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The 1.8 A crystal structure of the dimeric peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: implications for substrate binding and reaction mechanism.
J.Mol.Biol., 273, 1997
6PCD
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BU of 6pcd by Molmil
Crystal structure of beta-ketoadipyl-CoA thiolase mutant (C90S-H356A) in complex Octanoyl coenzyme A
Descriptor: Beta-ketoadipyl-CoA thiolase, CHLORIDE ION, COENZYME A, ...
Authors:Sukritee, B, Panjikar, S.
Deposit date:2019-06-17
Release date:2020-05-27
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Structural basis for differentiation between two classes of thiolase: Degradative vs biosynthetic thiolase.
J Struct Biol X, 4, 2020
1QFL
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BU of 1qfl by Molmil
BIOSYNTHETIC THIOLASE FROM ZOOGLOEA RAMIGERA IN COMPLEX WITH A REACTION INTERMEDIATE.
Descriptor: COENZYME A, PROTEIN (ACETOACETYL-COA THIOLASE), SULFATE ION
Authors:Modis, Y, Wierenga, R.K.
Deposit date:1999-04-12
Release date:2000-04-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:A biosynthetic thiolase in complex with a reaction intermediate: the crystal structure provides new insights into the catalytic mechanism.
Structure Fold.Des., 7, 1999
3GOA
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BU of 3goa by Molmil
Crystal structure of the Salmonella typhimurium FadA 3-ketoacyl-CoA thiolase
Descriptor: 3-ketoacyl-CoA thiolase, CALCIUM ION, CHLORIDE ION, ...
Authors:Anderson, S.M, Skarina, T, Onopriyenko, O, Wawrzak, Z, Papazisi, L, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2009-03-18
Release date:2009-03-31
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:

7FEA
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BU of 7fea by Molmil
PY14 in complex with Col-D
Descriptor: (6~{R},7~{R},9~{E})-6,7-bis(oxidanyl)hexadeca-9,15-dien-11,13-diynoic acid, Acetyl-CoA C-acyltransferase
Authors:Lin, C.C, Ko, T.P, Huang, K.F, Yang, Y.L.
Deposit date:2021-07-19
Release date:2022-07-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors.
Commun Biol, 5, 2022
4ZRC
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BU of 4zrc by Molmil
Crystal structure of MSM-13, a putative T1-like thiolase from Mycobacterium smegmatis
Descriptor: Beta-ketothiolase
Authors:Janardan, N, Harijan, R.K, Keima, T.R, Wierenga, R, Murthy, M.R.N.
Deposit date:2015-05-12
Release date:2016-05-18
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural characterization of a mitochondrial 3-ketoacyl-CoA (T1)-like thiolase from Mycobacterium smegmatis
Acta Crystallogr.,Sect.D, 71, 2015
5ONC
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BU of 5onc by Molmil
Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis is Controlled by a Redox-Sensitive Thiol Switch
Descriptor: CHLORIDE ION, Steroid 3-ketoacyl-CoA thiolase
Authors:Schaefer, C, Kuper, J, Sampson, N.S, Kisker, C.
Deposit date:2017-08-03
Release date:2017-08-23
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch.
ACS Infect Dis, 3, 2017
5LP7
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BU of 5lp7 by Molmil
Crystal structure of 3-Ketoacyl-CoA Thiolase (MmgA) from Bacillus subtilis.
Descriptor: Acetyl-CoA acetyltransferase, GLYCEROL
Authors:Baker, G.E, Race, P.R.
Deposit date:2016-08-11
Release date:2016-08-24
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of 3-Ketoacyl-CoA Thiolase (MmgA) from Bacillus subtilis.
To Be Published
1ULQ
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BU of 1ulq by Molmil
Crystal structure of tt0182 from Thermus thermophilus HB8
Descriptor: putative acetyl-CoA acetyltransferase
Authors:Ago, H, Hamada, K, Ida, K, Kanda, H, Sugahara, M, Yamamoto, M, Kuroishi, C, Kuramitsu, S, Yokoyama, S, Miyano, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-09-16
Release date:2004-11-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of tt0182 from Thermus thermophilus HB8
To be Published
1M3Z
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BU of 1m3z by Molmil
Biosynthetic thiolase, C89A mutant, complexed with acetyl coenzyme A
Descriptor: ACETYL COENZYME *A, Acetyl-CoA acetyltransferase, SULFATE ION
Authors:Kursula, P, Ojala, J, Lambeir, A.-M, Wierenga, R.K.
Deposit date:2002-07-03
Release date:2002-11-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The catalytic cycle of biosynthetic thiolase: A conformational journey of an acetyl group through four binding modes and two oxyanion holes
Biochemistry, 41, 2002
4XL2
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Crystal structure of oxidized form of thiolase from Clostridium acetobutylicum
Descriptor: ACETATE ION, Acetyl-CoA acetyltransferase, DI(HYDROXYETHYL)ETHER, ...
Authors:Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J.
Deposit date:2015-01-13
Release date:2015-10-07
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum
Nat Commun, 6, 2015
4XL3
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Crystal structure of reduced form of thiolase from Clostridium acetobutylicum
Descriptor: Acetyl-CoA acetyltransferase, GLYCEROL
Authors:Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J.
Deposit date:2015-01-13
Release date:2015-10-07
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum
Nat Commun, 6, 2015
7CW4
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BU of 7cw4 by Molmil
Acetyl-CoA acetyltransferase from Bacillus cereus ATCC 14579
Descriptor: Acetyl-CoA acetyltransferase, GLYCEROL
Authors:Hong, J, Kim, K.J.
Deposit date:2020-08-27
Release date:2020-10-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Crystal structure of an acetyl-CoA acetyltransferase from PHB producing bacterium Bacillus cereus ATCC 14579.
Biochem.Biophys.Res.Commun., 533, 2020
4E1L
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BU of 4e1l by Molmil
Crystal structure of Acetoacetyl-CoA thiolase (thlA2) from Clostridium difficile
Descriptor: Acetoacetyl-CoA thiolase 2, IODIDE ION
Authors:Anderson, S.M, Wawrzak, Z, Kudritska, M, Peterson, S.N, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-03-06
Release date:2012-03-21
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:

7CW5
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BU of 7cw5 by Molmil
Acetyl-CoA acetyltransferase from Bacillus cereus ATCC 14579
Descriptor: Acetyl-CoA acetyltransferase, COENZYME A
Authors:Hong, J, Kim, K.J.
Deposit date:2020-08-27
Release date:2020-10-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of an acetyl-CoA acetyltransferase from PHB producing bacterium Bacillus cereus ATCC 14579.
Biochem.Biophys.Res.Commun., 533, 2020
7XLY
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BU of 7xly by Molmil
Crystal structure of FadA2 (Rv0243) from the fatty acid metabolic pathway of Mycobacterium tuberculosis
Descriptor: Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (Beta-ketothiolase), SULFATE ION
Authors:Singh, R, Kundu, P, Singh, B.K, Bhattacharyya, S, Das, A.K.
Deposit date:2022-04-23
Release date:2023-04-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of FadA2 thiolase from Mycobacterium tuberculosis and prediction of its substrate specificity and membrane-anchoring properties.
Febs J., 290, 2023
3SS6
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BU of 3ss6 by Molmil
Crystal structure of the Bacillus anthracis acetyl-CoA acetyltransferase
Descriptor: Acetyl-CoA acetyltransferase, POTASSIUM ION, SULFATE ION
Authors:Anderson, S.M, Wawrzak, Z, Onopriyenko, O, Peterson, S.N, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2011-07-07
Release date:2011-07-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of the Bacillus anthracis acetyl-CoA acetyltransferase
TO BE PUBLISHED
6L2G
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BU of 6l2g by Molmil
Crystal structure of Aspergillus fumigatus mitochondrial acetyl-CoA acetyltransferase
Descriptor: Acetyl-CoA-acetyltransferase, putative
Authors:Zhang, Y, Wei, W, Raimi, O.G, Ferenbach, A.T, Fang, W.
Deposit date:2019-10-03
Release date:2020-02-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Aspergillus fumigatus Mitochondrial Acetyl Coenzyme A Acetyltransferase as an Antifungal Target.
Appl.Environ.Microbiol., 86, 2020
6L2C
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BU of 6l2c by Molmil
Crystal structure of Aspergillus fumigatus mitochondrial acetyl-CoA acetyltransferase in complex with CoA
Descriptor: Acetyl-CoA-acetyltransferase, putative, COENZYME A
Authors:Zhang, Y, Wei, W, Raimi, O.G, Ferenbach, A.T, Fang, W.
Deposit date:2019-10-03
Release date:2020-02-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Aspergillus fumigatus Mitochondrial Acetyl Coenzyme A Acetyltransferase as an Antifungal Target.
Appl.Environ.Microbiol., 86, 2020
4DD5
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BU of 4dd5 by Molmil
Biosynthetic Thiolase (ThlA1) from Clostridium difficile
Descriptor: Acetyl-CoA acetyltransferase
Authors:Filippova, E.V, Wawrzak, Z, Kudritska, M, Edwards, A, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-01-18
Release date:2012-02-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Biosynthetic Thiolase (ThlA1) from Clostridium difficile
To be Published
7VTR
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BU of 7vtr by Molmil
3-ketoacyl-CoA thiolase Tfu_0875
Descriptor: Thiolase
Authors:Liu, L.X, Zhou, S.H, Deng, Y.
Deposit date:2021-10-30
Release date:2022-11-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Rational Design of the Substrate Tunnel of beta-Ketothiolase Reveals a Local Cationic Domain Modulated Rule that Improves the Efficiency of Claisen Condensation
Acs Catalysis, 13, 2023
3SVK
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BU of 3svk by Molmil
Crystal structure of Acetyl-CoA acetyltransferase from Mycobacterium avium
Descriptor: Acetyl-CoA acetyltransferase, CHLORIDE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-07-12
Release date:2011-08-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
6PCA
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BU of 6pca by Molmil
Crystal structure of beta-ketoadipyl-CoA thiolase
Descriptor: ACETATE ION, Beta-ketoadipyl-CoA thiolase, CHLORIDE ION, ...
Authors:Sukritee, B, Panjikar, S.
Deposit date:2019-06-17
Release date:2020-05-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural basis for differentiation between two classes of thiolase: Degradative vs biosynthetic thiolase.
J Struct Biol X, 4, 2020
6PCB
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BU of 6pcb by Molmil
Crystal structure of beta-ketoadipyl-CoA thiolase mutant (H356A) in complex with COA
Descriptor: Beta-ketoadipyl-CoA thiolase, CHLORIDE ION, COENZYME A, ...
Authors:Sukritee, B, Panjikar, S.
Deposit date:2019-06-17
Release date:2020-05-27
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Structural basis for differentiation between two classes of thiolase: Degradative vs biosynthetic thiolase.
J Struct Biol X, 4, 2020
1DLU
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BU of 1dlu by Molmil
UNLIGANDED BIOSYNTHETIC THIOLASE FROM ZOOGLOEA RAMIGERA
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, BIOSYNTHETIC THIOLASE, SULFATE ION
Authors:Modis, Y, Wierenga, R.K.
Deposit date:1999-12-12
Release date:2000-04-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystallographic analysis of the reaction pathway of Zoogloea ramigera biosynthetic thiolase.
J.Mol.Biol., 297, 2000

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