PDB: 202 resultsInfo pagesStatus searchChemie searchBIRD

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3WGW	Structure of PCNA bound to a small molecule inhibitor Descriptor: 4-{4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol, Proliferating cell nuclear antigen, SULFATE ION Authors: Hashimoto, H. Deposit date: 2013-08-12 Release date: 2014-02-05 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.8 Å) Cite: A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J.Biol.Chem., 289, 2014
8COB	Crystal structure of human PCNA in complex with ERCC6L2 PIP box peptide Descriptor: DNA excision repair protein ERCC-6-like 2, Proliferating cell nuclear antigen Authors: Ariza, A. Deposit date: 2023-02-27 Release date: 2023-04-19 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.73 Å) Cite: ERCC6L2 mitigates replication stress and promotes centromere stability. Cell Rep, 42, 2023
3L0X	Structure of split yeast PCNA Descriptor: Proliferating cell nuclear antigen Authors: Freudenthal, B.D, Gakhar, L, Ramaswamy, S, Washington, M.T. Deposit date: 2009-12-10 Release date: 2010-03-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3 Å) Cite: Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange. Nat.Struct.Mol.Biol., 17, 2010
6WAC	FF248-249AA PCNA mutant defective in BIR Descriptor: Proliferating cell nuclear antigen Authors: Ripley, B.M, Washington, M.T. Deposit date: 2020-03-25 Release date: 2020-09-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural analysis of PCNA mutant proteins defective in BIR, FF248-249AA and R80A To be Published
4CS5	Crystal Structure of PCNA from Litopenaeus vannamei Descriptor: PROLIFERATING CELL NUCLEAR ANTIGEN Authors: Carrasco-Miranda, J.S, Lopez-Zavala, A.A, De-La-Mora, E, Rudino-Pinera, E, Brieba, L.G, Sotelo-Mundo, R.R. Deposit date: 2014-03-04 Release date: 2014-04-23 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal Structure of the Shrimp Proliferating Cell Nuclear Antigen: Structural Complementarity with Wssv DNA Polymerase Pip-Box. Plos One, 9, 2014
1AXC	HUMAN PCNA Descriptor: P21/WAF1, PCNA Authors: Gulbis, J.M, Kuriyan, J. Deposit date: 1997-10-14 Release date: 1998-01-28 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell(Cambridge,Mass.), 87, 1996
4RJF	Crystal structure of the human sliding clamp at 2.0 angstrom resolution Descriptor: Cyclin-dependent kinase inhibitor 1, Proliferating cell nuclear antigen Authors: Kroker, A.J, Bruning, J.B. Deposit date: 2014-10-09 Release date: 2015-08-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.0072 Å) Cite: p21 Exploits Residue Tyr151 as a Tether for High-Affinity PCNA Binding. Biochemistry, 54, 2015
6O09	Structure of AtPCNA in complex with the PIP motif of ATXR6 Descriptor: Proliferating cellular nuclear antigen 1, Uncharacterized protein Authors: Couture, J.F, Davarinejad, H. Deposit date: 2019-02-15 Release date: 2019-03-27 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.06 Å) Cite: ATXR5/6 Forms Alternative Protein Complexes with PCNA and the Nucleosome Core Particle. J. Mol. Biol., 431, 2019
8B8T	Open conformation of the complex of DNA ligase I on PCNA and DNA in the presence of ATP Descriptor: DNA ligase 1, Proliferating cell nuclear antigen Authors: Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A. Deposit date: 2022-10-05 Release date: 2023-01-11 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing. Nat Commun, 13, 2022
4D2G	Crystal structure of human PCNA in complex with p15 peptide Descriptor: P15, PROLIFERATING CELL NUCLEAR ANTIGEN Authors: DeBiasio, A, Ibanez, A, Mortuza, G, Molina, R, Cordeiro, T.N, Castillo, F, Villate, M, Merino, N, Lelli, M, Diercks, T, Luque, I, Bernardo, P, Montoya, G, Blanco, F.J. Deposit date: 2014-05-09 Release date: 2015-03-18 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structure of P15(Paf)-PCNA Complex and Implications for Clamp Sliding During DNA Replication and Repair. Nat.Commun., 6, 2015
7WP3	Crystal structure of the complex of proliferating cell nuclear antigen (PCNA) from Leishmania donovani with 1,5-Bis (4-amidinophenoxy) pentane (PNT) at 2.95 A resolution Descriptor: 1,5-BIS(4-AMIDINOPHENOXY)PENTANE, Proliferating cell nuclear antigen Authors: Ahmad, M.I, Yadav, S.P, Singh, P.K, Sharma, P, Kaur, P, Sharma, S, Singh, T.P. Deposit date: 2022-01-22 Release date: 2022-06-15 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.954 Å) Cite: Crystal structure of the complex of proliferating cell nuclear antigen (PCNA) from Leishmania donovani with 1,5-Bis (4-amidinophenoxy) pentane (PNT) at 2.95 A resolution To Be Published
1GE8	PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) HOMOLOG FROM PYROCOCCUS FURIOSUS Descriptor: PROLIFERATION CELL NUCLEAR ANTIGEN Authors: Matsumiya, S, Ishino, Y, Morikawa, K. Deposit date: 2000-10-18 Release date: 2001-01-24 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of an archaeal DNA sliding clamp: proliferating cell nuclear antigen from Pyrococcus furiosus. Protein Sci., 10, 2001
5T9D	Structure of PCNA acetylated on K20 Descriptor: Proliferating cell nuclear antigen Authors: Couture, J.F, Tremblay, V, Brunzelle, J.S. Deposit date: 2016-09-09 Release date: 2017-04-05 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.27 Å) Cite: Structure of PCNA acetylated on K20 To Be Published
5MLO	Crystal structure of human PCNA in complex with ZRANB3 PIP box peptide Descriptor: Proliferating cell nuclear antigen, SODIUM ION, ZRANB3 PIP box peptide Authors: Ariza, A. Deposit date: 2016-12-07 Release date: 2017-06-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Structural insights into the function of ZRANB3 in replication stress response. Nat Commun, 8, 2017
7EP8	Crystal structure of PCNA from Neurospora crassa Descriptor: Proliferating cell nuclear antigen Authors: Sundaram, R, Vasudevan, D. Deposit date: 2021-04-26 Release date: 2021-06-30 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Interdomain connecting loop and J loop structures determine cross-species compatibility of PCNA. J.Biol.Chem., 297, 2021
6W9W	R80A PCNA mutant defective in BIR Descriptor: Proliferating cell nuclear antigen Authors: Ripley, B.M, Washington, M.T. Deposit date: 2020-03-23 Release date: 2020-09-23 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structural analysis of PCNA mutant proteins defective in BIR, FF248-249AA and R80A To be Published
5MOM	Crystal Structure of PCNA encoding the hypomorphic mutation S228I Descriptor: Proliferating cell nuclear antigen Authors: Biasutto, A.J, Mancini, E.J, Green, C.M, Wilson, R.H.C. Deposit date: 2016-12-14 Release date: 2017-01-25 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.27 Å) Cite: PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions. DNA Repair (Amst.), 50, 2017
5MLW	Crystal structure of human PCNA in complex with ZRANB3 APIM motif peptide Descriptor: APIM motif peptide, Proliferating cell nuclear antigen, SULFATE ION Authors: Ariza, A. Deposit date: 2016-12-07 Release date: 2017-06-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Structural insights into the function of ZRANB3 in replication stress response. Nat Commun, 8, 2017
5MAV	Crystal structure of human PCNA in complex with PARG (poly(ADP-ribose) glycohydrolase) peptide. Descriptor: Poly (ADP-ribose) glycohydrolase, Proliferating cell nuclear antigen Authors: Grishkovskaya, I, Djinovic-Carugo, K, Slade, D. Deposit date: 2016-11-06 Release date: 2017-08-02 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.575 Å) Cite: A novel non-canonical PIP-box mediates PARG interaction with PCNA. Nucleic Acids Res., 45, 2017
6FCM	Crystal structure of human PCNA Descriptor: Proliferating cell nuclear antigen Authors: Housset, D, Frachet, P. Deposit date: 2017-12-20 Release date: 2019-01-30 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils. J.Exp.Med., 216, 2019
6FCN	Crystal structure of human PCNA soaked with p47phox(106-127) peptide Descriptor: Proliferating cell nuclear antigen Authors: Housset, D, Frachet, P. Deposit date: 2017-12-20 Release date: 2019-01-30 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.22 Å) Cite: Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils. J.Exp.Med., 216, 2019
2NTI	Crystal structure of PCNA123 heterotrimer. Descriptor: 2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL, BROMIDE ION, DNA polymerase sliding clamp A, ... Authors: Hlinkova, V, Ling, H. Deposit date: 2006-11-07 Release date: 2007-12-18 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structures of monomeric, dimeric and trimeric PCNA: PCNA-ring assembly and opening. Acta Crystallogr.,Sect.D, 64, 2008
3F1W	Crystal structure of a mutant proliferating cell nuclear antigen that blocks translesion synthesis Descriptor: Proliferating cell nuclear antigen Authors: Freudenthal, B.D, Ramaswamy, S, Washington, M.T. Deposit date: 2008-10-28 Release date: 2008-12-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.901 Å) Cite: Structure of a Mutant Form of Proliferating Cell Nuclear Antigen That Blocks Translesion DNA Synthesis. Biochemistry, 47, 2008
2OD8	Structure of a peptide derived from Cdc9 bound to PCNA Descriptor: DNA ligase I, mitochondrial precursor, Proliferating cell nuclear antigen Authors: Chapados, B.R, Tainer, J.A. Deposit date: 2006-12-21 Release date: 2007-05-01 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.8 Å) Cite: The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase. Nucleic Acids Res., 35, 2007
7EFA	Crystal structure of the complex between the C-terminal domain of mouse MUTYH and human PCNA Descriptor: Adenine DNA glycosylase, Proliferating cell nuclear antigen Authors: Nakamura, T, Nakabeppu, Y, Yamagata, Y. Deposit date: 2021-03-21 Release date: 2021-06-23 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer. Nucleic Acids Res., 49, 2021

 

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