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9IJE
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BU of 9ije by Molmil
Epinephrine-activated human beta3 adrenergic receptor
Descriptor: Beta-3 adrenergic receptor, Camelid antibody VHH fragment, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zheng, S, Zhang, S, Dai, S, Chen, K, Gao, K, Lin, B, Liu, X.
Deposit date:2024-06-22
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (2.34 Å)
Cite:Molecular Mechanism of the beta 3AR Agonist Activity of a beta-Blocker.
Chempluschem, 2024
9IJD
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BU of 9ijd by Molmil
Carazolol-activated human beta3 adrenergic receptor
Descriptor: (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, Beta-3 adrenergic receptor, Camelid antibody VHH fragment, ...
Authors:Zheng, S, Zhang, S, Dai, S, Chen, K, Gao, K, Lin, B, Liu, X.
Deposit date:2024-06-22
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Molecular Mechanism of the beta 3AR Agonist Activity of a beta-Blocker.
Chempluschem, 2024
9IJ9
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BU of 9ij9 by Molmil
A Cryo-EM structure of Bitter taste receptor TAS2R14 with Gi complex
Descriptor: 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Yuan, Q, Duan, J, Tao, L, Xu, E.H.
Deposit date:2024-06-21
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist.
Cell Res., 2024
9IIX
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BU of 9iix by Molmil
A Cryo-EM structure of Bitter taste receptor TAS2R14 with Ggust
Descriptor: 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Yuan, Q, Duan, J, Tao, L, Xu, E.H.
Deposit date:2024-06-21
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist.
Cell Res., 2024
9ERX
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BU of 9erx by Molmil
Structural basis of D9-THC analog activity at the Cannabinoid 1 receptor
Descriptor: (6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol, Antibody ScFv16 Fab fragment, Cannabinoid receptor 1, ...
Authors:Thorsen, T.S, Kulkarni, Y, Boggild, A, Drace, T, Nissen, P, Gajhede, M, Boesen, T, Kastrup, J.S, Gloriam, D.
Deposit date:2024-03-25
Release date:2024-06-26
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of Delta 9 -THC analog activity at the Cannabinoid 1 receptor.
Res Sq, 2024
9BKK
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BU of 9bkk by Molmil
Cholecystokinin 1 receptor (CCK1R) sterol 7M mutant, Gq chimera (mGsqi) complex
Descriptor: Cholecystokinin receptor type A, Cholecystokinin-8, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Harikumar, K.G, Zhao, P, Cary, B.P, Xu, X, Desai, A.J, Mobbs, J.I, Toufaily, C, Furness, S.G.B, Christopoulos, A, Belousoff, M.J, Wootten, D, Sexton, P.M, Miller, L.J.
Deposit date:2024-04-29
Release date:2024-05-22
Last modified:2024-08-14
Method:ELECTRON MICROSCOPY (2.51 Å)
Cite:Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling.
Plos Biol., 22, 2024
9BKJ
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BU of 9bkj by Molmil
Cholecystokinin 1 receptor (CCK1R) Y140A mutant, Gq chimera (mGsqi) complex
Descriptor: AMINO GROUP, Cholecystokinin receptor type A, Cholecystokinin-8, ...
Authors:Cary, B.P, Harikumar, K.G, Zhao, P, Desai, A.J, Mobbs, J.M, Toufaily, C, Furness, S.G.B, Christopoulos, A, Belousoff, M.J, Wootten, D, Sexton, P.M, Miller, L.J.
Deposit date:2024-04-29
Release date:2024-05-22
Last modified:2024-08-14
Method:ELECTRON MICROSCOPY (2.59 Å)
Cite:Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling.
Plos Biol., 22, 2024
9AYF
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BU of 9ayf by Molmil
Structure of human calcium-sensing receptor in complex with Gi1 (miniGi1) protein in detergent
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, ...
Authors:Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R.
Deposit date:2024-03-07
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Promiscuous G-protein activation by the calcium-sensing receptor.
Nature, 629, 2024
9AXF
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BU of 9axf by Molmil
Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in detergent
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, ...
Authors:Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R.
Deposit date:2024-03-06
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Promiscuous G-protein activation by the calcium-sensing receptor.
Nature, 629, 2024
9AVL
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BU of 9avl by Molmil
Structure of human calcium-sensing receptor in complex with Gi3 protein in nanodiscs
Descriptor: (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R.
Deposit date:2024-03-04
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Promiscuous G-protein activation by the calcium-sensing receptor.
Nature, 629, 2024
9AVG
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BU of 9avg by Molmil
Structure of human calcium-sensing receptor in complex with chimeric Gs (miniGis) protein in nanodiscs
Descriptor: (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R.
Deposit date:2024-03-02
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Promiscuous G-protein activation by the calcium-sensing receptor.
Nature, 629, 2024
9AUC
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BU of 9auc by Molmil
Human Amylin1 Receptor in Complex with Gs and human Calcitonin Gene-Related Peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin gene-related peptide 1, ...
Authors:Cao, J, Belousoff, M.J, Wootten, D.L, Sexton, P.M.
Deposit date:2024-02-28
Release date:2024-04-24
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein.
Biochemistry, 63, 2024
9ASB
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BU of 9asb by Molmil
Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in nanodiscs
Descriptor: (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R.
Deposit date:2024-02-24
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Promiscuous G-protein activation by the calcium-sensing receptor.
Nature, 629, 2024
8ZSV
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BU of 8zsv by Molmil
Cryo-EM structure of the RO5263397-bound mTAAR1-Gs complex
Descriptor: (4~{S})-4-(3-fluoranyl-2-methyl-phenyl)-1,3-oxazolidin-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Jiang, K.X, Zheng, Y, Xu, F.
Deposit date:2024-06-05
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules.
Cell Rep, 43, 2024
8ZSS
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BU of 8zss by Molmil
Cryo-EM structure of the RO5263397-bound hTAAR1-Gs complex
Descriptor: (4~{S})-4-(3-fluoranyl-2-methyl-phenyl)-1,3-oxazolidin-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Jiang, K.X, Zheng, Y, Xu, F.
Deposit date:2024-06-05
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules.
Cell Rep, 43, 2024
8ZSP
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BU of 8zsp by Molmil
Cryo-EM structure of the LSD-bound hTAAR1-Gs complex
Descriptor: (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Jiang, K.X, Zheng, Y, Xu, F.
Deposit date:2024-06-05
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules.
Cell Rep, 43, 2024
8ZSJ
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BU of 8zsj by Molmil
Cryo-EM structure of the apo hTAAR1-Gs complex
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Jiang, K.X, Zheng, Y, Xu, F.
Deposit date:2024-06-05
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules.
Cell Rep, 43, 2024
8ZRK
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BU of 8zrk by Molmil
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist GSK-1292263
Descriptor: 5-[4-[[6-(4-methylsulfonylphenyl)pyridin-3-yl]oxymethyl]piperidin-1-yl]-3-propan-2-yl-1,2,4-oxadiazole, Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Wong, T.S, Xiong, T.T, Zeng, Z.C, Gan, S.Y, Qiu, C, Du, Y.
Deposit date:2024-06-04
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:Cryo-EM structure of GPR119-Gs complex
To be published
8ZR5
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BU of 8zr5 by Molmil
Cryo-EM Structure of GPR119-Gs-Firuglipel complex
Descriptor: 4-[5-[(1~{R})-1-(4-cyclopropylcarbonylphenoxy)propyl]-1,2,4-oxadiazol-3-yl]-2-fluoranyl-~{N}-[(2~{R})-1-oxidanylpropan-2-yl]benzamide, Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Wong, T.S, Zeng, Z.C, Xiong, T.T, Gan, S.Y, Qiu, C, Du, Y.
Deposit date:2024-06-04
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Cryo-EM structure of GPR119-Gs complex
To Be Published
8ZJE
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BU of 8zje by Molmil
Cryo-EM structure of kisspeptin receptor bound to TAK-448
Descriptor: ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Shen, S, Liu, H, Xu, H.E.
Deposit date:2024-05-14
Release date:2024-07-03
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Cryo-EM structure of kisspeptin receptor bound to TAK-448
To Be Published
8ZJD
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BU of 8zjd by Molmil
Cryo-EM structure of kisspeptin receptor bound to KP-10
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, ...
Authors:Shen, S, Liu, H, Xu, H.E.
Deposit date:2024-05-14
Release date:2024-07-03
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Cryo-EM structure of kisspeptin receptor bound to KP-10
To Be Published
8ZH8
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BU of 8zh8 by Molmil
Human GPR103 -Gq complex bound to QRFP26
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2,Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Iwama, A, Akasaka, H, Sano, F.K, Oshima, H.S, Shihoya, W, Nureki, O.
Deposit date:2024-05-10
Release date:2024-07-03
Method:ELECTRON MICROSCOPY (3.19 Å)
Cite:Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103.
Nat Commun, 15, 2024
8ZFJ
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BU of 8zfj by Molmil
cryo-EM structure of GPR4-Gs complex at pH 8.5
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Ma, Y, Tang, M, Ru, H, Song, G.
Deposit date:2024-05-07
Release date:2024-08-07
Last modified:2024-08-14
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:cryo-EM structure of GPR4-Gs complex at pH 8.5
to be published
8ZCJ
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BU of 8zcj by Molmil
Cryo-EM structure of the pasireotide-bound SSTR5-Gi complex
Descriptor: 004-DTR-LYS-TYR-PHA-HYP, Beta-2 adrenergic receptor,Somatostatin receptor type 5,lgbit (fusion protein), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Li, Y.G, Meng, X.Y, Yang, X.R, Ling, S.L, Shi, P, Tian, C.L, Yang, F.
Deposit date:2024-04-29
Release date:2024-07-10
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Structural insights into somatostatin receptor 5 bound with cyclic peptides.
Acta Pharmacol.Sin., 2024
8ZBE
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BU of 8zbe by Molmil
cryo-EM structure of the octreotide-bound SSTR5-Gi complex
Descriptor: Beta-2 adrenergic receptor,Somatostatin receptor type 5,lgbit (fusion protein), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Li, Y.G, Meng, X.Y, Yang, X.R, Ling, S.L, Shi, P, Tian, C.L, Yang, F.
Deposit date:2024-04-26
Release date:2024-07-10
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Structural insights into somatostatin receptor 5 bound with cyclic peptides.
Acta Pharmacol.Sin., 2024

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PDB entries from 2024-09-18

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