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1AGR
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1agr
COMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS4
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), RGS4, GUANOSINE-5'-DIPHOSPHATE, CITRIC ACID
Authors:Tesmer, J.J.G., Sprang, S.R.
Deposit date:1997-03-25
Release date:1997-06-16
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis.
Cell(Cambridge,Mass.), 89, 1997
1AS0
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1as0
GTP-GAMMA-S BOUND G42V GIA1
Descriptor:GIA1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Authors:Raw, A.S., Coleman, D.E., Gilman, A.G., Sprang, S.R.
Deposit date:1997-08-11
Release date:1997-11-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.
Biochemistry, 36, 1997
1AS2
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1as2
GDP+PI BOUND G42V GIA1
Descriptor:GIA1, GUANOSINE-5'-DIPHOSPHATE
Authors:Raw, A.S., Coleman, D.E., Gilman, A.G., Sprang, S.R.
Deposit date:1997-08-11
Release date:1997-11-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.
Biochemistry, 36, 1997
1AS3
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1as3
GDP BOUND G42V GIA1
Descriptor:GIA1, GUANOSINE-5'-DIPHOSPHATE
Authors:Raw, A.S., Coleman, D.E., Gilman, A.G., Sprang, S.R.
Deposit date:1997-08-11
Release date:1997-11-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.
Biochemistry, 36, 1997
1AZT
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1azt
GS-ALPHA COMPLEXED WITH GTP-GAMMA-S
Descriptor:GS-ALPHA, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Authors:Tesmer, J.J.G., Sprang, S.R.
Deposit date:1997-11-20
Release date:1998-02-25
Modification date:2013-08-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the adenylyl cyclase activator Gsalpha
Science, 278, 1997
1BH2
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1bh2
A326S MUTANT OF AN INHIBITORY ALPHA SUBUNIT
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Authors:Mixon, M.B., Posner, B.A., Wall, M.A., Gilman, A.G., Sprang, S.R.
Deposit date:1998-06-12
Release date:1998-11-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The A326S mutant of Gialpha1 as an approximation of the receptor-bound state.
J.Biol.Chem., 273, 1998
1BOF
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1bof
GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM
Descriptor:GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE
Authors:Coleman, D.E., Sprang, S.R.
Deposit date:1998-08-04
Release date:1999-01-06
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of the G protein Gi alpha 1 complexed with GDP and Mg2+: a crystallographic titration experiment.
Biochemistry, 37, 1998
1CIP
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1cip
GI-ALPHA-1 SUBUNIT OF GUANINE NUCLEOTIDE-BINDING PROTEIN COMPLEXED WITH A GTP ANALOGUE
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT
Authors:Coleman, D., Sprang, S.
Deposit date:1999-04-05
Release date:1999-04-09
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complex.
J.Biol.Chem., 274, 1999
1FQJ
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1fqj
CRYSTAL STRUCTURE OF THE HETEROTRIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, THE GAMMA SUBUNIT OF PHOSPHODIESTERASE AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(PDEGAMMA)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)]
Descriptor:HETEROTRIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, THE GAMMA SUBUNIT OF PHOSPHODIESTERASE AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(PDEGAMMA)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)]
Authors:Slep, K.C., Kercher, M.A., He, W., Cowan, C.W., Wensel, T.G., Sigler, P.B.
Deposit date:2000-09-05
Release date:2001-02-28
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A.
Nature, 409, 2001
1FQK
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1fqk
CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)]
Descriptor:HETERODIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)]
Authors:Slep, K.C., Kercher, M.A., He, W., Cowan, C.W., Wensel, T.G., Sigler, P.B.
Deposit date:2000-09-05
Release date:2001-02-28
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A.
Nature, 409, 2001
1GDD
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1gdd
TERTIARY AND QUATERNARY STRUCTURAL CHANGES IN GIA1 INDUCED BY GTP HYDROLYSIS
Descriptor:GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE
Authors:Mixon, M.B., Sprang, S.R.
Deposit date:1995-07-25
Release date:1995-11-27
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis.
Science, 270, 1995
1GFI
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1gfi
STRUCTURES OF ACTIVE CONFORMATIONS OF GI ALPHA 1 AND THE MECHANISM OF GTP HYDROLYSIS
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT (G(I)-ALPHA-1) (ACTIVE FORM) COMPLEXED WITH GDP-ALF4
Authors:Coleman, D.E., Berghuis, A.M., Sprang, S.R.
Deposit date:1994-11-11
Release date:1995-03-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
Science, 265, 1994
1GG2
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1gg2
G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND
Descriptor:G PROTEIN GI ALPHA 1, G PROTEIN GI BETA 1, G PROTEIN GI GAMMA 2, GUANOSINE-5'-DIPHOSPHATE
Authors:Wall, M.A., Sprang, S.R.
Deposit date:1996-11-13
Release date:1997-02-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.
Cell(Cambridge,Mass.), 83, 1995
1GIA
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1gia
STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS
Descriptor:GI ALPHA 1 (ACTIVE FORM WITH BOUND GTP-GAMMA-S)
Authors:Berghuis, A.M., Coleman, D.E., Sprang, S.R.
Deposit date:1994-07-20
Release date:1994-09-30
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
Science, 265, 1994
1GIL
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1gil
STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS
Descriptor:G I ALPHA1 (GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT) MUTANT WITH GLN 204 REPLACED BY LEU (Q204L) COMPLEXED WITH GTP-GAMMA-S AND MAGNESIUM
Authors:Coleman, D.E., Berghuis, A.M., Sprang, S.R.
Deposit date:1995-01-02
Release date:1995-02-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
Science, 265, 1994
1GIT
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1git
STRUCTURE OF GTP-BINDING PROTEIN
Descriptor:G PROTEIN GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE
Authors:Berghuis, A.M., Lee, E., Sprang, S.R.
Deposit date:1996-10-16
Release date:1997-02-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis.
Structure, 4, 1996
1GOT
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1got
HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS
Descriptor:GT-ALPHA/GI-ALPHA CHIMERA, GT-BETA, GT-GAMMA, GUANOSINE-5'-DIPHOSPHATE
Authors:Lambright, D.G., Sondek, J., Bohm, A., Skiba, N.P., Hamm, H.E., Sigler, P.B.
Deposit date:1996-08-07
Release date:1997-03-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2.0 A crystal structure of a heterotrimeric G protein.
Nature, 379, 1996
1GP2
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1gp2
G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND
Descriptor:G PROTEIN GI ALPHA 1, G PROTEIN GI BETA 1, G PROTEIN GI GAMMA 2, GUANOSINE-5'-DIPHOSPHATE
Authors:Wall, M.A., Sprang, S.R.
Deposit date:1996-11-13
Release date:1997-02-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.
Cell(Cambridge,Mass.), 83, 1995
1KJY
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1kjy
CRYSTAL STRUCTURE OF HUMAN G[ALPHA]I1 BOUND TO THE GOLOCO MOTIF OF RGS14
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT, REGULATOR OF G-PROTEIN SIGNALING 14
Authors:Kimple, R.J., Kimple, M.E., Betts, L., Sondek, J., Siderovski, D.P.
Deposit date:2001-12-05
Release date:2002-05-08
Modification date:2011-11-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits.
Nature, 416, 2002
1SHZ
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1shz
CRYSTAL STRUCTURE OF THE P115RHOGEF RGRGS DOMAIN IN A COMPLEX WITH GALPHA(13):GALPHA(I1) CHIMERA
Descriptor:Guanine Nucleotide-Binding Protein Galpha(13):Galpha(i1) Chimera, Rho guanine nucleotide exchange factor 1
Authors:Chen, Z., Singer, W.D., Sternweis, P.C., Sprang, S.R.
Deposit date:2004-02-26
Release date:2005-01-18
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator.
Nat.Struct.Mol.Biol., 12, 2005
1SVK
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1svk
STRUCTURE OF THE K180P MUTANT OF GI ALPHA SUBUNIT BOUND TO ALF4 AND GDP
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit (E.C.3.6.1.46)
Authors:Thomas, C.J., Du, X., Li, P., Wang, Y., Ross, E.M., Sprang, S.R.
Deposit date:2004-03-29
Release date:2004-06-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein {alpha}-subunit.
Proc.Natl.Acad.Sci.USA, 101, 2004
1SVS
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1svs
STRUCTURE OF THE K180P MUTANT OF GI ALPHA SUBUNIT BOUND TO GPPNHP.
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit
Authors:Thomas, C.J., Du, X., Li, P., Wang, Y., Ross, E.M., Sprang, S.R.
Deposit date:2004-03-29
Release date:2004-06-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein {alpha}-subunit.
Proc.Natl.Acad.Sci.USA, 101, 2004
1TAD
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1tad
GTPASE MECHANISM OF GPROTEINS FROM THE 1.7-ANGSTROM CRYSTAL STRUCTURE OF TRANSDUCIN ALPHA-GDP-ALF4-
Descriptor:TRANSDUCIN-ALPHA (GT-ALPHA-GDP-ALF, T-ALPHA-GDP-ALF) COMPLEXED WITH GDP AND ALUMINUM FLUORIDE
Authors:Sondek, J., Lambright, D.G., Noel, J.P., Hamm, H.E., Sigler, P.B.
Deposit date:1995-01-05
Release date:1995-05-08
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4.
Nature, 372, 1994
1TAG
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1tag
STRUCTURAL DETERMINANTS FOR ACTIVATION OF THE ALPHA-SUBUNIT OF A HETEROTRIMERIC G PROTEIN
Descriptor:TRANSDUCIN-ALPHA COMPLEXED WITH GDP AND MAGNESIUM (GT-ALPHA-GDP, T-ALPHA-GDP)
Authors:Lambright, D.G., Noel, J.P., Hamm, H.E., Sigler, P.B.
Deposit date:1994-11-23
Release date:1995-02-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein.
Nature, 369, 1994
1TND
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1tnd
THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S
Descriptor:TRANSDUCIN (ALPHA SUBUNIT) COMPLEXED WITH THE NONHYDROLYZABLE GTP ANALOGUE GTP GAMMA S
Authors:Noel, J.P., Hamm, H.E., Sigler, P.B.
Deposit date:1994-03-31
Release date:1994-07-31
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S.
Nature, 366, 1993
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