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9FCJ
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BU of 9fcj by Molmil
USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (ordered subset, focused refinement)
Descriptor: 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, Polyubiquitin-C, Ubiquitin carboxyl-terminal hydrolase 1, ...
Authors:Rennie, M.L, Gundogdu, M, Walden, H.
Deposit date:2024-05-15
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279.
J.Med.Chem., 2024
9FCI
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BU of 9fci by Molmil
USP1 bound to KSQ-4279 and ubiquitin conjugated to FANCD2 (focused refinement)
Descriptor: 6-(4-cyclopropyl-6-methoxy-pyrimidin-5-yl)-1-[[4-[1-propan-2-yl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine, Polyubiquitin-C, Ubiquitin carboxyl-terminal hydrolase 1, ...
Authors:Rennie, M.L, Gundogdu, M, Walden, H.
Deposit date:2024-05-15
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279.
J.Med.Chem., 2024
8C61
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BU of 8c61 by Molmil
Structure of USP54 in complex with Lys63-linked diUbiquitin-PA
Descriptor: CHLORIDE ION, Inactive ubiquitin carboxyl-terminal hydrolase 54, Polyubiquitin-B, ...
Authors:Wendrich, K, Gersch, M.
Deposit date:2023-01-11
Release date:2024-07-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of USP54 in complex with Lys63 linked diUbiquitin-PA
To be published
8QPA
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BU of 8qpa by Molmil
Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-10-01
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
8R0B
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BU of 8r0b by Molmil
Cryo-EM structure of the cross-exon pre-B+ATP complex
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-10-31
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
8QPK
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BU of 8qpk by Molmil
Cryo-EM Structure of Pre-B+5'ss Complex (core part)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-10-02
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
8R09
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BU of 8r09 by Molmil
Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-10-31
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
8QOZ
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BU of 8qoz by Molmil
Cryo-EM Structure of Pre-B+5'ss+ATPgammaS Complex (core part)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss RNA oligo, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-09-29
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
8QP8
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BU of 8qp8 by Molmil
Cryo-EM Structure of Pre-B Complex (core part)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, INOSITOL HEXAKISPHOSPHATE, Pre-mRNA-processing factor 6, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-09-30
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
8R0A
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BU of 8r0a by Molmil
Cryo-EM structure of the cross-exon pre-B+5'ss complex
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-10-31
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
8QXD
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BU of 8qxd by Molmil
Cryo-EM structure of the cross-exon pre-B complex
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, NHP2-like protein 1, N-terminally processed, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-10-24
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (9.6 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
8QP9
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BU of 8qp9 by Molmil
Cryo-EM Structure of Pre-B+AMPPNP Complex (core part)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, INOSITOL HEXAKISPHOSPHATE, Pre-mRNA-processing factor 6, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-09-30
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
8QPB
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BU of 8qpb by Molmil
Cryo-EM Structure of Pre-B+ATP Complex (core part)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-10-01
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
8R08
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BU of 8r08 by Molmil
Cryo-EM structure of the cross-exon pre-B+AMPPNP complex
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, NHP2-like protein 1, N-terminally processed, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-10-31
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
8QPE
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BU of 8qpe by Molmil
Cryo-EM Structure of Pre-B-like Complex (core part)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, INOSITOL HEXAKISPHOSPHATE, Microfibrillar-associated protein 1, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-10-01
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
8QZS
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BU of 8qzs by Molmil
Cryo-EM structure of the cross-exon B-like complex
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, Microfibrillar-associated protein 1, NHP2-like protein 1, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-10-29
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
8P1Q
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BU of 8p1q by Molmil
USP28 in complex with FT206
Descriptor: 3-azanyl-N-[(2S)-6-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-1,2,3,4-tetrahydronaphthalen-2-yl]-6-methyl-thieno[2,3-b]pyridine-2-carboxamide, DIMETHYL SULFOXIDE, Ubiquitin carboxyl-terminal hydrolase 28
Authors:Sauer, F, Karal Nair, R, Kisker, C.
Deposit date:2023-05-12
Release date:2024-05-22
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:USP28 in complex with FT206
To Be Published
8P19
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BU of 8p19 by Molmil
USP28 USP domain apo
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 28
Authors:Sauer, F, Karal Nair, R, Kisker, C.
Deposit date:2023-05-11
Release date:2024-05-22
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:USP28 USP domain apo
To Be Published
8P14
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BU of 8p14 by Molmil
USP28 USP domain in complex with Vismodegib
Descriptor: 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide, CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 28
Authors:Sauer, F, Karal Nair, R, Kisker, C.
Deposit date:2023-05-11
Release date:2024-05-22
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:USP28 USP domain in complex with Vismodegib
To Be Published
8P1P
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BU of 8p1p by Molmil
USP28 in complex with AZ1
Descriptor: 2-[[5-bromanyl-2-[[4-fluoranyl-3-(trifluoromethyl)phenyl]methoxy]phenyl]methylamino]ethanol, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Sauer, F, Karal-Nair, R, Kisker, C.
Deposit date:2023-05-12
Release date:2024-05-22
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:USP28 in complex with AZ1
To Be Published
8RM5
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BU of 8rm5 by Molmil
Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'SS oligo, NHP2-like protein 1, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2024-01-05
Release date:2024-05-22
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (6.9 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 630, 2024
8H6J
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BU of 8h6j by Molmil
Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state.
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Zhang, W, Zhan, X, Zhang, X, Lei, J, Yan, C, Shi, Y.
Deposit date:2022-10-18
Release date:2024-05-01
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Structural insights into human exon-defined spliceosome prior to activation.
Cell Res., 34, 2024
8H6E
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BU of 8h6e by Molmil
Cryo-EM structure of human exon-defined spliceosome in the late pre-B state.
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y.
Deposit date:2022-10-17
Release date:2024-05-01
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural insights into human exon-defined spliceosome prior to activation.
Cell Res., 34, 2024
8ITP
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BU of 8itp by Molmil
Crystal structure of USP47 catalytic domain complex with ubiquitin
Descriptor: Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 47, ZINC ION
Authors:Kim, E.E, Shin, S.C.
Deposit date:2023-03-22
Release date:2024-03-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and functional characterization of USP47 reveals a hot spot for inhibitor design.
Commun Biol, 6, 2023
8ITN
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BU of 8itn by Molmil
Crystal structure of USP47apo catalytic domain
Descriptor: Ubiquitin carboxyl-terminal hydrolase 47, ZINC ION
Authors:Kim, E.E, Shin, S.C.
Deposit date:2023-03-22
Release date:2024-03-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional characterization of USP47 reveals a hot spot for inhibitor design.
Commun Biol, 6, 2023

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PDB entries from 2024-09-18

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