1BBS
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X-RAY ANALYSES OF PEPTIDE INHIBITOR COMPLEXES DEFINE THE STRUCTURAL BASIS OF SPECIFICITY FOR HUMAN AND MOUSE RENINS
Descriptor:RENIN (E.C.3.4.23.15)
Authors:Dhanaraj, V., Blundell, T.L.
Deposit date:1992-05-21
Release date:1994-01-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins.
Nature, 357, 1992
1BIL
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CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS
Descriptor:RENIN, DIMETHYLFORMAMIDE, N-METHYL-N-(METHYLBENZYL)FORMAMIDE, 2-METHYL-3-(2-AMINOTHIAZOLO)PROPANAL, 1-HYDROXY-2-AMINO-3-CYCLOHEXYLPROPANE, 1-HYDROXY-3-METHYLBUTANE
Authors:Tong, L.
Deposit date:1995-09-27
Release date:1996-01-29
Modification date:2012-01-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors.
J.Biol.Chem., 270, 1995
1BIM
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CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS
Descriptor:RENIN, DIMETHYLFORMAMIDE, N-METHYL-N-(METHYLBENZYL)FORMAMIDE, 2-METHYL-3-(2-AMINOTHIAZOLO)PROPANAL, 1-HYDROXY-2-AMINO-3-CYCLOHEXYLPROPANE, 1-METHYL-2-OXY-5,5-DIMETHYL PYRROLIDINE
Authors:Tong, L.
Deposit date:1995-09-27
Release date:1996-01-29
Modification date:2012-01-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors.
J.Biol.Chem., 270, 1995
1CMS
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THE THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT BOVINE CHYMOSIN AT 2.3 ANGSTROMS RESOLUTION
Descriptor:CHYMOSIN B (FORMERLY KNOWN AS RENNIN) (E.C.3.4.23.4)
Authors:Gilliland, G.L., Winborne, E.L., Nachman, J., Wlodawer, A.
Deposit date:1989-10-12
Release date:1990-01-15
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The three-dimensional structure of recombinant bovine chymosin at 2.3 A resolution.
Proteins, 8, 1990
1CZI
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CHYMOSIN COMPLEX WITH THE INHIBITOR CP-113972
Descriptor:CHYMOSIN, CP-113972 (NORSTATINE-S-METHYL CYSTEINE-IODO-PHENYLALANINE-PROLINE)
Authors:Groves, M.R., Dhanaraj, V., Pitts, J.E., Badasso, M., Hoover, D., Nugent, P., Blundell, T.L.
Deposit date:1997-01-15
Release date:1997-04-01
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A 2.3 A resolution structure of chymosin complexed with a reduced bond inhibitor shows that the active site beta-hairpin flap is rearranged when compared with the native crystal structure.
Protein Eng., 11, 1998
1F34
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CRYSTAL STRUCTURE OF ASCARIS PEPSIN INHIBITOR-3 BOUND TO PORCINE PEPSIN
Descriptor:PEPSIN A (E.C.3.4.23.1)/MAJOR PEPSIN INHIBITOR PI-3
Authors:Ng, K.K., Petersen, J.F., Cherney, M.M., Garen, C., James, M.N.
Deposit date:2000-05-31
Release date:2001-02-01
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3.
Nat.Struct.Biol., 7, 2000
1FKN
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STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR
Descriptor:MEMAPSIN 2 (E.C.3.4.23.46), INHIBITOR
Authors:Hong, L., Koelsch, G., Lin, X., Wu, S., Terzyan, S., Ghosh, A., Zhang, X.C., Tang, J.
Deposit date:2000-08-09
Release date:2000-10-09
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor.
Science, 290, 2000
1FLH
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CRYSTAL STRUCTURE OF HUMAN UROPEPSIN AT 2.45 A RESOLUTION
Descriptor:HUMAN UROPEPSIN (E.C.3.4.23.1)
Authors:Canduri, F., Teodoro, L.G.V.L., Fadel, V., Lorenzi, C.C.B., Hial, V., Gomes, R.A.S., Neto, J.R., De Azevedo Jr., W.F.
Deposit date:2000-08-14
Release date:2001-10-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure of human uropepsin at 2.45 A resolution.
Acta Crystallogr.,Sect.D, 57, 2001
1FMU
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STRUCTURE OF NATIVE PROTEINASE A IN P3221 SPACE GROUP.
Descriptor:SACCHAROPEPSIN (E.C. 3.4.23.25)
Authors:Gustchina, A., Li, M., Phylip, L.H., Lees, W.E., Kay, J., Wlodawer, A.
Deposit date:2000-08-18
Release date:2002-07-31
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:An unusual orientation for Tyr75 in the active site of the aspartic proteinase from Saccharomyces cerevisiae.
Biochem.Biophys.Res.Commun., 295, 2002
1FMX
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STRUCTURE OF NATIVE PROTEINASE A IN THE SPACE GROUP P21
Descriptor:SACCHAROPEPSIN (E.C. 3.4.23.25)
Authors:Gustchina, A., Li, M., Phylip, L.H., Lees, W.E., Kay, J., Wlodawer, A.
Deposit date:2000-08-18
Release date:2002-07-31
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:An unusual orientation for Tyr75 in the active site of the aspartic proteinase from Saccharomyces cerevisiae.
Biochem.Biophys.Res.Commun., 295, 2002
1FQ4
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CRYSTAL STRUCTURE OF A COMPLEX BETWEEN HYDROXYETHYLENE INHIBITOR CP-108,420 AND YEAST ASPARTIC PROTEINASE A
Descriptor:SACCHAROPEPSIN (E.C.3.4.23.25)
Authors:Cronin, N.B., Badasso, M.O., Tickle, I.J., Dreyer, T., Hoover, D.J., Rosati, R.L., Humblet, C.C., Lunney, E.A., Cooper, J.B.
Deposit date:2000-09-03
Release date:2000-09-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.
J.Mol.Biol., 303, 2000
1FQ5
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X-RAY STRUTURE OF A CYCLIC STATINE INHIBITOR PD-129,541 BOUND TO YEAST PROTEINASE A
Descriptor:SACCHAROPEPSIN (E.C.3.4.23.25)
Authors:Cronin, N.B., Badasso, M.O., Tickle, I.J., Dreyer, T., Hoover, D.J., Rosati, R.L., Humblet, C.C., Lunney, E.A., Cooper, J.B.
Deposit date:2000-09-03
Release date:2000-09-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.
J.Mol.Biol., 303, 2000
1FQ6
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X-RAY STRUCTURE OF GLYCOL INHIBITOR PD-133,450 BOUND TO SACCHAROPEPSIN
Descriptor:SACCHAROPEPSIN (E.C.3.4.23.25)
Authors:Cronin, N.B., Badasso, M.O., Tickle, I.J., Dreyer, T., Hoover, D.J., Rosati, R.L., Humblet, C.C., Lunney, E.A., Cooper, J.B.
Deposit date:2000-09-03
Release date:2000-09-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.
J.Mol.Biol., 303, 2000
1FQ7
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X-RAY STRUCTURE OF INHIBITOR CP-72,647 BOUND TO SACCHAROPEPSIN
Descriptor:SACCHAROPEPSIN (E.C.3.4.23.25)
Authors:Cronin, N.B., Badasso, M.O., Tickle, I.J., Dreyer, T., Hoover, D.J., Rosati, R.L., Humblet, C.C., Lunney, E.A., Cooper, J.B.
Deposit date:2000-09-04
Release date:2000-09-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.
J.Mol.Biol., 303, 2000
1FQ8
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X-RAY STRUCTURE OF DIFLUOROSTATINE INHIBITOR CP81,198 BOUND TO SACCHAROPEPSIN
Descriptor:SACCHAROPEPSIN (E.C.3.4.23.25)
Authors:Cronin, N.B., Badasso, M.O., Tickle, I.J., Dreyer, T., Hoover, D.J., Rosati, R.L., Humblet, C.C., Lunney, E.A., Cooper, J.B.
Deposit date:2000-09-04
Release date:2000-09-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.
J.Mol.Biol., 303, 2000
1HRN
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HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS
Descriptor:RENIN COMPLEXED WITH POLYHYDROXYMONOAMIDE INHIBITOR BILA 980
Authors:Tong, L., Anderson, P.C.
Deposit date:1995-03-31
Release date:1995-06-03
Modification date:2011-08-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors.
J.Mol.Biol., 250, 1995
1LS5
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CRYSTAL STRUCTURE OF PLASMEPSIN IV FROM P. FALCIPARUM IN COMPLEX WITH PEPSTATIN A
Descriptor:PLASMEPSIN IV
Authors:Asojo, O.A., Gulnik, S.V., Afonina, E., Yu, B., Ellman, J.A., Haque, T.S., Silva, A.M.
Deposit date:2002-05-16
Release date:2002-06-12
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum.
J.Mol.Biol., 327, 2003
1M4H
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CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR OM00-3
Descriptor:Beta-secretase (E.C.3.4.23.-)
Authors:Hong, L., Turner, R.T., Koelsch, G., Ghosh, A.K., Tang, J.
Deposit date:2002-07-02
Release date:2002-08-28
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Memapsin 2 (beta-Secretase) in Complex with Inhibitor OM00-3
Biochemistry, 41, 2002
1PSA
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STRUCTURE OF A PEPSIN(SLASH)RENIN INHIBITOR COMPLEX REVEALS A NOVEL CRYSTAL PACKING INDUCED BY MINOR CHEMICAL ALTERATIONS IN THE INHIBITOR
Descriptor:PEPSIN HYDROLASE (ACID PROTEINASE) (E.C.3.4.23.1) COMPLEX WITH A-62095
Authors:Chen, L., Abad-Zapatero, C.
Deposit date:1991-10-22
Release date:1994-01-31
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a pepsin/renin inhibitor complex reveals a novel crystal packing induced by minor chemical alterations in the inhibitor.
Acta Crystallogr.,Sect.B, 48, 1992
1PSN
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THE CRYSTAL STRUCTURE OF HUMAN PEPSIN AND ITS COMPLEX WITH PEPSTATIN
Descriptor:PEPSIN 3A (E.C.3.4.23.1)
Authors:Fujinaga, M., Chernaia, M.M., Tarasova, N., Mosimann, S.C., James, M.N.G.
Deposit date:1995-01-23
Release date:1995-04-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of human pepsin and its complex with pepstatin.
Protein Sci., 4, 1995
1PSO
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THE CRYSTAL STRUCTURE OF HUMAN PEPSIN AND ITS COMPLEX WITH PEPSTATIN
Descriptor:PEPSIN 3A (E.C.3.4.23.1) COMPLEXED WITH PEPSTATIN
Authors:Fujinaga, M., Chernaia, M.M., Tarasova, N., Mosimann, S.C., James, M.N.G.
Deposit date:1995-01-23
Release date:1995-04-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human pepsin and its complex with pepstatin.
Protein Sci., 4, 1995
1QRP
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HUMAN PEPSIN 3A IN COMPLEX WITH A PHOSPHONATE INHIBITOR IVA-VAL-VAL-LEU(P)-(O)PHE-ALA-ALA-OME
Descriptor:PEPSIN 3A
Authors:Fujinaga, M., Cherney, M.M., Tarasova, N.I., Bartlett, P.A., Hanson, J.E., James, M.N.G.
Deposit date:1999-06-15
Release date:1999-06-18
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structural study of the complex between human pepsin and a phosphorus-containing peptidic -transition-state analog.
Acta Crystallogr.,Sect.D, 56, 2000
1RNE
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THE CRYSTAL STRUCTURE OF RECOMBINANT GLYCOSYLATED HUMAN RENIN ALONE AND IN COMPLEX WITH A TRANSITION STATE ANALOG INHIBITOR
Descriptor:RENIN (ACTIVATED, GLYCOSYLATED, INHIBITED) (E.C.3.4.23.15) COMPLEX WITH CGP 38'560
Authors:Gruetter, M.G., Rahuel, J., Priestle, J.P.
Deposit date:1991-12-12
Release date:1993-10-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structures of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor.
J.Struct.Biol., 107, 1991
1SGZ
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CRYSTAL STRUCTURE OF UNBOUND BETA-SECRETASE CATALYTIC DOMAIN.
Descriptor:Beta-secretase (E.C.3.4.23.46)
Authors:Hong, L., Tang, J.
Deposit date:2004-02-24
Release date:2004-05-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Flap Position of Free Memapsin 2 (beta-Secretase), a Model for Flap Opening in Aspartic Protease Catalysis
Biochemistry, 43, 2004
1SMR
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THE 3-D STRUCTURE OF MOUSE SUBMAXILLARY RENIN COMPLEXED WITH A DECAPEPTIDE INHIBITOR CH-66 BASED ON THE 4-16 FRAGMENT OF RAT ANGIOTENSINOGEN
Descriptor:RENIN (E.C.3.4.23.15) COMPLEX WITH THE INHIBITOR CH-66
Authors:Dealwis, C.G., Blundell, T.L.
Deposit date:1992-03-11
Release date:1994-01-31
Modification date:2012-02-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen.
J.Mol.Biol., 236, 1994
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