4UUZ
 
 | | MCM2-histone complex | | Descriptor: | DNA REPLICATION LICENSING FACTOR MCM2, HISTONE H3, HISTONE H4 | | Authors: | Richet, N, Liu, D, Legrand, P, Bakail, M, Compper, C, Besle, A, Guerois, R, Ochsenbein, F. | | Deposit date: | 2014-08-01 | | Release date: | 2015-02-11 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural Insight Into How the Human Helicase Subunit Mcm2 May Act as a Histone Chaperone Together with Asf1 at the Replication Fork.
Nucleic Acids Res., 43, 2015
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9BCX
 | | Cryo-EM structure of the S. cerevisiae ORC-Cdc6-Mcm2-7-DNA complex with a fully closed Mcm2-Mcm5 DNA entry gate | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA (39-MER), ... | | Authors: | Yuan, Z, Bai, L, Li, H, Speck, C. | | Deposit date: | 2024-04-10 | | Release date: | 2025-01-01 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (6.1 Å) | | Cite: | MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis.
Nat Commun, 16, 2025
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5BK4
 | | Cryo-EM structure of Mcm2-7 double hexamer on dsDNA | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (60-mer), strand 1, ... | | Authors: | Li, H, Yuan, Z, Bai, L. | | Deposit date: | 2017-09-12 | | Release date: | 2017-10-25 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5V8F
 | | Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 | | Descriptor: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (39-MER), ... | | Authors: | Yuan, Z, Riera, A, Bai, L, Sun, J, Spanos, C, Chen, Z.A, Barbon, M, Rappsilber, J, Stillman, B, Speck, C, Li, H. | | Deposit date: | 2017-03-21 | | Release date: | 2017-05-10 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.
Nat. Struct. Mol. Biol., 24, 2017
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5XF8
 | | Cryo-EM structure of the Cdt1-MCM2-7 complex in AMPPNP state | | Descriptor: | Cell division cycle protein CDT1, DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, ... | | Authors: | Zhai, Y, Cheng, E, Wu, H, Li, N, Yung, P.Y, Gao, N, Tye, B.K. | | Deposit date: | 2017-04-09 | | Release date: | 2017-05-03 | | Last modified: | 2025-03-12 | | Method: | ELECTRON MICROSCOPY (7.1 Å) | | Cite: | Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer
Nat. Struct. Mol. Biol., 24, 2017
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5BNX
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5BO0
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5BNV
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7PT7
 | | Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ADP:BeF3, state I | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 7, ... | | Authors: | Saleh, A, Noguchi, Y, Aramayo, R, Ivanova, M.E, Speck, C. | | Deposit date: | 2021-09-26 | | Release date: | 2022-06-08 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer.
Nat Commun, 13, 2022
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7PT6
 | | Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ATPgS, state III | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 7, DDK kinase regulatory subunit DBF4, ... | | Authors: | Saleh, A, Noguchi, Y, Aramayo, R, Ivanova, M.E, Speck, C. | | Deposit date: | 2021-09-26 | | Release date: | 2022-06-08 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer.
Nat Commun, 13, 2022
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7W68
 | | human single hexameric Mcm2-7 complex | | Descriptor: | DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ... | | Authors: | Xu, N.N, Lin, Q.P, Liu, C.D, Tian, H.L, Xiang, Y, Zhu, G. | | Deposit date: | 2021-12-01 | | Release date: | 2023-03-08 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | human single hexameric Mcm2-7 complex
To Be Published
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5C3I
 | | Crystal structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2 | | Descriptor: | DNA replication licensing factor MCM2,MCM2, Histone H3.1, Histone H4, ... | | Authors: | Wang, H, Wang, M, Yang, N, Xu, R.M. | | Deposit date: | 2015-06-17 | | Release date: | 2015-07-29 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2
Protein Cell, 6, 2015
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8YJF
 | | Structure of human SPT16 MD-CTD and MCM2 HBD chaperoning a histone H3-H4 tetramer and an H2A-H2B dimer | | Descriptor: | DNA replication licensing factor MCM2, FACT complex subunit SPT16, Histone H2A type 1-D, ... | | Authors: | Gan, S.L, Yang, W.S, Xu, R.M. | | Deposit date: | 2024-03-01 | | Release date: | 2024-03-20 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (4.4 Å) | | Cite: | Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2.
Sci China Life Sci, 67, 2024
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8YJM
 | | Structure of human SPT16 MD-CTD and MCM2 HBD chaperoning a histone H3-H4 tetramer and a single chain H2B-H2A chimera | | Descriptor: | DNA replication licensing factor MCM2, FACT complex subunit SPT16, Histone H2B 1/2/3/4/6,Histone H2A type 1-D, ... | | Authors: | Gan, S.L, Yang, W.S, Xu, R.M. | | Deposit date: | 2024-03-02 | | Release date: | 2024-03-20 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (4.15 Å) | | Cite: | Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2.
Sci China Life Sci, 67, 2024
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3ZXU
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5MU3
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9CAQ
 | | Cryo-EM structure of a human MCM2-7 double hexamer formed from independently loaded MCM2-7 single hexamers | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (44-MER), ... | | Authors: | Yang, R, Hunker, O, Bleichert, F. | | Deposit date: | 2024-06-17 | | Release date: | 2024-10-02 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Multiple mechanisms for licensing human replication origins.
Nature, 636, 2024
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6WGF
 | | Atomic model of mutant Mcm2-7 hexamer with Mcm6 WHD truncation | | Descriptor: | DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ... | | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | | Deposit date: | 2020-04-05 | | Release date: | 2020-07-15 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (7.7 Å) | | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 117, 2020
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8W0I
 | | Cryo-EM structure of the human MCM2-7 heterohexamer | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA replication licensing factor MCM2, ... | | Authors: | Yang, R, Hunker, O, Bleichert, F. | | Deposit date: | 2024-02-13 | | Release date: | 2024-10-02 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Multiple mechanisms for licensing human replication origins.
Nature, 636, 2024
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8W0E
 | | Cryo-EM structure of a human MCM2-7 single hexamer on dsDNA | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (25-MER), ... | | Authors: | Hunker, O, Yang, R, Bleichert, F. | | Deposit date: | 2024-02-13 | | Release date: | 2024-10-02 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Multiple mechanisms for licensing human replication origins.
Nature, 636, 2024
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8W0G
 | | Cryo-EM structure of a human MCM2-7 dimer | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA replication licensing factor MCM2, ... | | Authors: | Yang, R, Hunker, O, Bleichert, F. | | Deposit date: | 2024-02-13 | | Release date: | 2024-10-02 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Multiple mechanisms for licensing human replication origins.
Nature, 636, 2024
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8W0F
 | | Cryo-EM structure of a human MCM2-7 double hexamer on dsDNA | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (47-MER), ... | | Authors: | Hunker, O, Yang, R, Bleichert, F. | | Deposit date: | 2024-02-13 | | Release date: | 2024-10-02 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Multiple mechanisms for licensing human replication origins.
Nature, 636, 2024
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6WGG
 | | Atomic model of pre-insertion mutant OCCM-DNA complex(ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) | | Descriptor: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (41-MER), ... | | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | | Deposit date: | 2020-04-05 | | Release date: | 2020-07-15 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (8.1 Å) | | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6.
Proc.Natl.Acad.Sci.USA, 117, 2020
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7CJ0
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7CIZ
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