PDB Search results for query - Protein Data Bank Japan

PDB: 72 results Info pages Status search Chemie search BIRD

Crystal structure of SAM-bound METTL3-METTL14 complex
Descriptor:	1,2-ETHANEDIOL, METTL14, METTL3, ...
Authors:	Wang, X, Guan, Z, Zou, T, Yin, P.
Deposit date:	2016-03-04
Release date:	2016-05-25
Last modified:	2016-06-29
Method:	X-RAY DIFFRACTION (1.71 Å)
Cite:	Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex Nature, 534, 2016

5IL2

Crystal structure of SAH-bound METTL3-METTL14 complex
Descriptor:	1,2-ETHANEDIOL, METTL14, METTL3, ...
Authors:	Wang, X, Guan, Z, Zou, T, Yin, P.
Deposit date:	2016-03-04
Release date:	2016-05-25
Last modified:	2016-06-29
Method:	X-RAY DIFFRACTION (1.606 Å)
Cite:	Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex Nature, 534, 2016

5IL0

Crystal structural of the METTL3-METTL14 complex for N6-adenosine methylation
Descriptor:	1,2-ETHANEDIOL, BROMIDE ION, METTL14, ...
Authors:	Wang, X, Guan, Z, Zou, T, Yin, P.
Deposit date:	2016-03-04
Release date:	2016-05-25
Last modified:	2016-06-29
Method:	X-RAY DIFFRACTION (1.882 Å)
Cite:	Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex Nature, 534, 2016

5K7U

Crystal structure of the catalytic domains of Mettl3/Mettl14 complex with SAM
Descriptor:	N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase subunit METTL14, S-ADENOSYLMETHIONINE
Authors:	Wang, P, Doxtader, K.A, Nam, Y.
Deposit date:	2016-05-26
Release date:	2016-07-06
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. Mol.Cell, 63, 2016

5K7M

Crystal structure of the catalytic domains of Mettl3/Mettl14 complex
Descriptor:	N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase subunit METTL14
Authors:	Wang, P, Doxtader, K.A, Nam, Y.
Deposit date:	2016-05-26
Release date:	2016-07-06
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. Mol.Cell, 63, 2016

5K7W

Crystal structure of the catalytic domain of Mettl3/Mettl14 complex with SAH
Descriptor:	N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase subunit METTL14, S-ADENOSYL-L-HOMOCYSTEINE
Authors:	Wang, P, Doxtader, K.A, Nam, Y.
Deposit date:	2016-05-26
Release date:	2016-07-06
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. Mol.Cell, 63, 2016

5TEY

Human METTL3-METTL14 complex
Descriptor:	1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, MAGNESIUM ION, ...
Authors:	DONG, A, ZENG, H, LI, Y, TEMPEL, W, Seitova, A, Hutchinson, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC)
Deposit date:	2016-09-23
Release date:	2016-11-23
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Human METTL3-METTL14 complex to be published

5YZ9

zinc finger domain of METTL3-METTL14 N6-methyladenosine methyltransferase
Descriptor:	N6-adenosine-methyltransferase catalytic subunit, ZINC ION
Authors:	Dong, X, Tang, C, Gong, Z, Yin, P, Huang, J.B.
Deposit date:	2017-12-13
Release date:	2018-03-28
Last modified:	2024-05-01
Method:	SOLUTION NMR, SOLUTION SCATTERING
Cite:	Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. Protein Cell, 10, 2019

7L4X

YTH Domain of Human YTHDC1 with dsDNA Comprising Single N6mA joined by two six-bp DNA duplexes in P3221 Crystal
Descriptor:	1,2-ETHANEDIOL, YTH domain-containing protein 1, ssDNA w/N6A
Authors:	Horton, J.R, Cheng, X.
Deposit date:	2020-12-21
Release date:	2021-11-03
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.79 Å)
Cite:	Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions. Nucleic Acids Res., 49, 2021

7L4Y

YTH Domain of Human YTHDC1 with dsDNA Comprising Single N6mA joined by Two Six-bp DNA Duplexes in P212121 Crystal
Descriptor:	1,2-ETHANEDIOL, YTH domain-containing protein 1, ssDNA 13mer
Authors:	Horton, J.R, Cheng, X.
Deposit date:	2020-12-21
Release date:	2021-11-03
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.79 Å)
Cite:	Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions. Nucleic Acids Res., 49, 2021

5L6D

Crystal structure of the human METTL3-METTL14 complex bound to SAH
Descriptor:	ACETATE ION, MAGNESIUM ION, N6-adenosine-methyltransferase 70 kDa subunit, ...
Authors:	Sledz, P, Jinek, M.
Deposit date:	2016-05-29
Release date:	2016-10-12
Method:	X-RAY DIFFRACTION (1.852 Å)
Cite:	Structural insights into the molecular mechanism of the m(6)A writer complex. Elife, 5, 2016

5L6E

Crystal structure of the human METTL3-METTL14 complex bound to SAM
Descriptor:	ACETATE ION, MAGNESIUM ION, N6-adenosine-methyltransferase 70 kDa subunit, ...
Authors:	Sledz, P, Jinek, M.
Deposit date:	2016-05-29
Release date:	2016-10-12
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.901 Å)
Cite:	Structural insights into the molecular mechanism of the m(6)A writer complex. Elife, 5, 2016

7RX6

Structure of METTL3-METTL14(R298C) mutant methyltransferase complex
Descriptor:	N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase non-catalytic subunit
Authors:	Wang, P, Nam, Y.
Deposit date:	2021-08-21
Release date:	2022-11-09
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Structure of METTL3-METTL14(R298C) mutant methyltransferase complex To Be Published

7RX7

Structure of METTL3-METTL14(R298P) mutant methyltransferase complex
Descriptor:	N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase non-catalytic subunit
Authors:	Wang, P, Nam, Y.
Deposit date:	2021-08-21
Release date:	2022-11-09
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.645 Å)
Cite:	Structure of METTL3-METTL14(R298P) mutant methyltransferase complex To Be Published

7RX8

Structure of METTL3-METTL14(R298H) mutant methyltransferase complex
Descriptor:	N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase non-catalytic subunit
Authors:	Wang, P, Nam, Y.
Deposit date:	2021-08-21
Release date:	2022-11-09
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Structure of METTL3-METTL14(R298H) mutant methyltransferase complex To Be Published

7O2X

Crystal structure of the human METTL3-METTL14 complex with compound T180
Descriptor:	ACETATE ION, N-[(6-methylimidazo[1,2-a]pyridin-2-yl)methyl]-4-oxidanylidene-pyrido[1,2-a]pyrimidine-2-carboxamide, N6-adenosine-methyltransferase catalytic subunit, ...
Authors:	Bedi, R.K, Huang, D, Caflisch, A.
Deposit date:	2021-03-31
Release date:	2021-04-07
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Crystal structure of the human METTL3-METTL14 complex with compound T180 To Be Published

7O0M

Crystal structure of the human METTL3-METTL14 complex bound to Compound 9 (ADO_AD_023)
Descriptor:	4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
Authors:	Bedi, R.K, Dolbois, A, Caflisch, A.
Deposit date:	2021-03-26
Release date:	2021-09-15
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.39 Å)
Cite:	Crystal structure of the human METTL3-METTL14 complex bound to Compound 9 (ADO_AD_023) To Be Published

7O0Q

Crystal structure of the human METTL3-METTL14 complex bound to Compound 12 (ADO_AD_066)
Descriptor:	3-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-8-[6-(methylamino)pyrimidin-4-yl]-1,3,8-triazaspiro[4.5]decan-2-one, ACETATE ION, MAGNESIUM ION, ...
Authors:	Bedi, R.K, Dolbois, A, Caflisch, A.
Deposit date:	2021-03-26
Release date:	2021-09-15
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.49 Å)
Cite:	Crystal structure of the human METTL3-METTL14 complex bound to Compound 12 (ADO_AD_066) To Be Published

7O2H

Crystal structure of the human METTL3-METTL14 complex bound to Compound 13 (ADO_AD_091)
Descriptor:	4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-1-methyl-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
Authors:	Bedi, R.K, Dolbois, A, Caflisch, A.
Deposit date:	2021-03-30
Release date:	2021-09-15
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Crystal structure of the human METTL3-METTL14 complex bound to Compound 13 (ADO_AD_091) To Be Published

7O0R

Crystal structure of the human METTL3-METTL14 complex bound to Compound 15 (ADO_AE_026)
Descriptor:	4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
Authors:	Bedi, R.K, Dolbois, A, Caflisch, A.
Deposit date:	2021-03-26
Release date:	2021-09-15
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Crystal structure of the human METTL3-METTL14 complex bound to Compound 15 (ADO_AE_026) To Be Published

7O27

Crystal structure of the human METTL3-METTL14 complex bound to Compound 17 (ADO_AE_005)
Descriptor:	4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
Authors:	Bedi, R.K, Dolbois, A, Caflisch, A.
Deposit date:	2021-03-30
Release date:	2021-09-15
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Crystal structure of the human METTL3-METTL14 complex bound to Compound 17 (ADO_AE_005) To Be Published

7O28

Crystal structure of the human METTL3-METTL14 complex bound to Compound 19 (ADO_AE_009)
Descriptor:	9-(2-chloranyl-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)-4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
Authors:	Bedi, R.K, Dolbois, A, Caflisch, A.
Deposit date:	2021-03-30
Release date:	2021-09-15
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.47 Å)
Cite:	Crystal structure of the human METTL3-METTL14 complex bound to Compound 19 (ADO_AE_009) To Be Published

7O0P

Crystal structure of the human METTL3-METTL14 complex bound to Compound 10 (ADO_AD_022)
Descriptor:	4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
Authors:	Bedi, R.K, Dolbois, A, Caflisch, A.
Deposit date:	2021-03-26
Release date:	2021-09-15
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Crystal structure of the human METTL3-METTL14 complex bound to Compound 10 (ADO_AD_022) To Be Published

7O2I

METTL3-METTL14 heterodimer bound to the SAM competitive small molecule inhibitor STM2457
Descriptor:	DIMETHYL SULFOXIDE, N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, ...
Authors:	Pilka, E.S, Blackaby, W, Hardick, D, Harper, C, Hewstone, D, Ridgill, M, Rotty, B, Rausch, O.
Deposit date:	2021-03-30
Release date:	2021-04-14
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia. Nature, 593, 2021

7O2F

Crystal structure of the human METTL3-METTL14 complex bound to Compound 22 (UZH2)
Descriptor:	4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2,5-bis(fluoranyl)phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
Authors:	Bedi, R.K, Dolbois, A, Caflisch, A.
Deposit date:	2021-03-30
Release date:	2021-09-01
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors. J.Med.Chem., 64, 2021

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Total results:	72
Displayed results:	25
Sorted by:	Hit score (from highest)
Query:	METTL14