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1M5I
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BU of 1m5i by Molmil
Crystal Structure of the coiled coil region 129-250 of the tumor suppressor gene product APC
Descriptor: APC protein
Authors:Tickenbrock, L, Cramer, J, Vetter, I.R, Mueller, O.
Deposit date:2002-07-09
Release date:2002-11-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1).
J.Biol.Chem., 277, 2002
1JHJ
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BU of 1jhj by Molmil
Crystal structure of the APC10/Doc1 subunit of the human anaphase-promoting complex
Descriptor: APC10, NICKEL (II) ION
Authors:Wendt, K.S, Vodermaier, H.C, Jacob, U, Gieffers, C, Gmachl, M, Peters, J.-M, Huber, R, Sondermann, P.
Deposit date:2001-06-28
Release date:2001-10-24
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex
Nat.Struct.Biol., 8, 2001
4YJE
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BU of 4yje by Molmil
Crystal structure of APC-ARM in complexed with Amer1-A1
Descriptor: APC membrane recruitment protein 1, Adenomatous polyposis coli protein
Authors:Zhang, Z, Xiao, Y, Wu, G.
Deposit date:2015-03-03
Release date:2016-03-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners
Cell Discov, 1, 2015
4YK6
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BU of 4yk6 by Molmil
Crystal structure of APC-ARM in complexed with Amer1-A4
Descriptor: APC membrane recruitment protein 1, Adenomatous polyposis coli protein
Authors:Zhang, Z, Xiao, Y, Wu, G.
Deposit date:2015-03-04
Release date:2016-03-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners
Cell Discov, 1, 2015
5FO3
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BU of 5fo3 by Molmil
ZapC cell division regulator from E. coli
Descriptor: CELL DIVISION PROTEIN ZAPC
Authors:Ortiz, C, Kureisaite-Ciziene, D, Schmitz, F, Vicente, M, Lowe, J.
Deposit date:2015-11-18
Release date:2015-11-25
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of the Z-Ring Associated Cell Division Protein Zapc from Escherichia Coli.
FEBS Lett., 589, 2015
8E0P
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BU of 8e0p by Molmil
Crystal structure of mouse APCDD1 in fusion with engineered MBP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[BENZYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE, CHLORIDE ION, ...
Authors:Hsieh, F.L, Chang, T.H, Gabelli, S.B, Nathans, J.
Deposit date:2022-08-09
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structure of WNT inhibitor adenomatosis polyposis coli down-regulated 1 (APCDD1), a cell-surface lipid-binding protein.
Proc.Natl.Acad.Sci.USA, 120, 2023
8E0W
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Crystal structure of mouse APCDD1 in P1 space group
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ...
Authors:Hsieh, F.L, Chang, T.H, Gabelli, S.B, Nathans, J.
Deposit date:2022-08-09
Release date:2023-05-10
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of WNT inhibitor adenomatosis polyposis coli down-regulated 1 (APCDD1), a cell-surface lipid-binding protein.
Proc.Natl.Acad.Sci.USA, 120, 2023
8E0R
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Crystal structure of mouse APCDD1 in P21 space group
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Protein APCDD1
Authors:Hsieh, F.L, Chang, T.H, Gabelli, S.B, Nathans, J.
Deposit date:2022-08-09
Release date:2023-05-10
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of WNT inhibitor adenomatosis polyposis coli down-regulated 1 (APCDD1), a cell-surface lipid-binding protein.
Proc.Natl.Acad.Sci.USA, 120, 2023
4YJL
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Crystal structure of APC-ARM in complexed with Amer1-A2
Descriptor: 1,2-ETHANEDIOL, APC membrane recruitment protein 1, Adenomatous polyposis coli protein
Authors:Zhang, Z, Xiao, Y, Wu, G.
Deposit date:2015-03-03
Release date:2016-03-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners
Cell Discov, 1, 2015
6Q6H
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BU of 6q6h by Molmil
Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class
Descriptor: Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, Anaphase-promoting complex subunit 13, ...
Authors:Zhang, S, Barford, D.
Deposit date:2018-12-11
Release date:2019-09-11
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C.
Nat Commun, 10, 2019
5Z8H
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APC with an inhibitor
Descriptor: Adenomatous polyposis coli protein, GLYCEROL, Peptide inhibitor
Authors:Zhang, J, Yang, X.Y, Song, K.
Deposit date:2018-01-31
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:APC with an inhibitor
To Be Published
7XTY
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BU of 7xty by Molmil
Crystal Structure of the second PDZ domain from human PTPN13 in complex with APC peptide
Descriptor: APC-peptide, Tyrosine-protein phosphatase non-receptor type 13
Authors:Jing, L.Q, Sun, X.N, Ma, W.H, Zhou, W.J, Wu, D.L.
Deposit date:2022-05-18
Release date:2023-05-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Targeting PTPN13 with 11 amino acid peptides of C-terminal APC prevents immune evasion of colorectal cancer
to be published
8GSJ
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BU of 8gsj by Molmil
APC-Asef tripeptide inhibitor
Descriptor: (1R,2S)-2-phenylcyclopropanamine, 2-methylsulfanylpyrimidine-4-carbaldehyde, Adenomatous polyposis coli protein, ...
Authors:Zhang, J, Wang, X.F, Song, K.
Deposit date:2022-09-06
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:APC-Asef tripeptide inhibitor
To Be Published
5JG6
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BU of 5jg6 by Molmil
APC11-Ubv shows role of noncovalent RING-Ubiquitin interactions in processive multiubiquitination and Ubiquitin chain elongation by APC/C
Descriptor: Anaphase-promoting complex subunit 11, Polyubiquitin-B, ZINC ION
Authors:Brown, N.G, Zhang, W, Yu, S, Miller, D.J, Sidhu, S.S, Schulman, B.A.
Deposit date:2016-04-19
Release date:2016-06-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.0013 Å)
Cite:Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
5ECD
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BU of 5ecd by Molmil
Structure of the Shigella flexneri VapC mutant D98N crystal form 1
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, tRNA(fMet)-specific endonuclease VapC
Authors:Xu, K.
Deposit date:2015-10-20
Release date:2016-02-17
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural analysis of the active site architecture of the VapC toxin from Shigella flexneri.
Proteins, 84, 2016
5ED0
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BU of 5ed0 by Molmil
Structure of the Shigella flexneri VapC mutant D7N
Descriptor: tRNA(fMet)-specific endonuclease VapC
Authors:Xu, K, Dedic, E, Brodersen, D.E.
Deposit date:2015-10-20
Release date:2016-02-17
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural analysis of the active site architecture of the VapC toxin from Shigella flexneri.
Proteins, 84, 2016
5ECW
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BU of 5ecw by Molmil
Structure of the Shigella flexneri VapC mutant D7A
Descriptor: tRNA(fMet)-specific endonuclease VapC
Authors:Xu, K, Dedic, E, Brodersen, D.E.
Deposit date:2015-10-20
Release date:2016-02-17
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structural analysis of the active site architecture of the VapC toxin from Shigella flexneri.
Proteins, 84, 2016
2KT6
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BU of 2kt6 by Molmil
Structural homology between the C-terminal domain of the PapC usher and its plug
Descriptor: Outer membrane usher protein papC
Authors:Ford, B, Rego, A, Ragan, T.J, Pinkner, J, Dodson, K, Driscoll, P.C, Hultgren, S, Waksman, G.
Deposit date:2010-01-19
Release date:2010-04-21
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structural Homology between the C-Terminal Domain of the PapC Usher and Its Plug.
J.Bacteriol., 192, 2010
3FIP
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BU of 3fip by Molmil
Crystal structure of Usher PapC translocation pore
Descriptor: Outer membrane usher protein papC
Authors:Huang, Y, Deisenhofer, J.
Deposit date:2008-12-12
Release date:2009-09-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.154 Å)
Cite:Insights into pilus assembly and secretion from the structure and functional characterization of usher PapC.
Proc.Natl.Acad.Sci.USA, 106, 2009
1DEB
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BU of 1deb by Molmil
CRYSTAL STRUCTURE OF THE N-TERMINAL COILED COIL DOMAIN FROM APC
Descriptor: ADENOMATOUS POLYPOSIS COLI PROTEIN, SULFATE ION
Authors:Day, C.L, Alber, T.
Deposit date:1999-11-14
Release date:2000-09-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the amino-terminal coiled-coil domain of the APC tumor suppressor.
J.Mol.Biol., 301, 2000
8TAU
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BU of 8tau by Molmil
APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G.
Deposit date:2023-06-27
Release date:2023-09-27
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Nat.Struct.Mol.Biol., 30, 2023
8TAR
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BU of 8tar by Molmil
APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G.
Deposit date:2023-06-27
Release date:2023-09-27
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Nat.Struct.Mol.Biol., 30, 2023
3ZN3
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BU of 3zn3 by Molmil
N-terminal domain of S. pombe Cdc23 APC subunit
Descriptor: ANAPHASE-PROMOTING COMPLEX SUBUNIT 8, MERCURY (II) ION
Authors:Zhang, Z, Yang, J, Conin, N, Kulkarni, K, Barford, D.
Deposit date:2013-02-13
Release date:2013-02-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Four Canonical Tpr Subunits of Human Apc/C Form Related Homo-Dimeric Structures and Stack in Parallel to Form a Tpr Suprahelix
J.Mol.Biol., 425, 2013
5A31
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Structure of the human APC-Cdh1-Hsl1-UbcH10 complex.
Descriptor: ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 10, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, ...
Authors:Chang, L, Zhang, Z, Yang, J, Mclaughlin, S.H, Barford, D.
Deposit date:2015-05-26
Release date:2015-11-18
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Atomic Structure of the Apc/C and its Mechanism of Protein Ubiquitination.
Nature, 522, 2015
4BH6
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Insights into degron recognition by APC coactivators from the structure of an Acm1-Cdh1 complex
Descriptor: APC/C ACTIVATOR PROTEIN CDH1, APC/C-CDH1 MODULATOR 1
Authors:He, J, Chao, W.C.H, Zhang, Z, Yang, J, Cronin, N, Barford, D.
Deposit date:2013-03-29
Release date:2013-06-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insights Into Degron Recognition by Apc/C Coactivators from the Structure of an Acm1-Cdh1 Complex.
Mol.Cell, 50, 2013

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