1MHJ
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1MHI
| THREE-DIMENSIONAL SOLUTION STRUCTURE OF AN INSULIN DIMER. A STUDY OF THE B9(ASP) MUTANT OF HUMAN INSULIN USING NUCLEAR MAGNETIC RESONANCE DISTANCE GEOMETRY AND RESTRAINED MOLECULAR DYNAMICS | Descriptor: | INSULIN | Authors: | Jorgensen, A.M.M, Kristensen, S.M, Led, J.J, Balschmidt, P. | Deposit date: | 1994-11-30 | Release date: | 1995-10-15 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | Three-dimensional solution structure of an insulin dimer. A study of the B9(Asp) mutant of human insulin using nuclear magnetic resonance, distance geometry and restrained molecular dynamics. J.Mol.Biol., 227, 1992
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1QIZ
| HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR COMPLEXED WITH RESORCINOL | Descriptor: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | Authors: | Tang, L, Whittingham, J.L, Verma, C.S, Caves, L.S.D, Dodson, G.G. | Deposit date: | 1999-06-18 | Release date: | 1999-06-22 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis. Biochemistry, 38, 1999
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7S4Y
| Serial Macromolecular Crystallography at ALBA Synchrotron Light Source - Insulin | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | Authors: | Martin-Garcia, J.M, Botha, S, Hu, H, Jernigan, R, Castellvi, A, Lisova, S, Gil, F, Calisto, B, Crespo, I, Roy-Chowdbury, S, Grieco, A, Ketawala, G, Weierstall, U, Spence, J, Fromme, P, Zatsepin, N, Boer, R, Carpena, X. | Deposit date: | 2021-09-09 | Release date: | 2021-10-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Serial macromolecular crystallography at ALBA Synchrotron Light Source. J.Synchrotron Radiat., 29, 2022
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3W7Z
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4AJZ
| Ligand controlled assembly of hexamers, dihexamers, and linear multihexamer structures by an engineered acylated insulin | Descriptor: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | Authors: | Steensgaard, D.B, Schluckebier, G, Strauss, H.M, Norrman, M, Thomsen, J.K, Friderichsen, A.V, Havelund, S, Jonassen, I. | Deposit date: | 2012-02-21 | Release date: | 2013-01-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Ligand Controlled Assembly of Hexamers, Dihexamers, and Linear Multihexamer Structures by the Engineered Acylated Insulin Degludec. Biochemistry, 52, 2013
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4AK0
| Ligand controlled assembly of hexamers, dihexamers, and linear multihexamer structures by an engineered acylated insulin | Descriptor: | INSULIN A CHAIN, INSULIN B CHAIN | Authors: | Steensgaard, D.B, Schluckebier, G, Strauss, H.M, Norrman, M, Thomsen, J.K, Friderichsen, A.V, Havelund, S, Jonassen, I. | Deposit date: | 2012-02-21 | Release date: | 2013-01-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Ligand Controlled Assembly of Hexamers, Dihexamers, and Linear Multihexamer Structures by the Engineered Acylated Insulin Degludec. Biochemistry, 52, 2013
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6QQ7
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6QQG
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4AKJ
| Ligand controlled assembly of hexamers, dihexamers, and linear multihexamer structures by an engineered acylated insulin | Descriptor: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | Authors: | Steensgaard, D.B, Schluckebier, G, Strauss, H.M, Norrman, M, Thomsen, J.K, Friderichsen, A.V, Havelund, S, Jonassen, I. | Deposit date: | 2012-02-23 | Release date: | 2013-01-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Ligand Controlled Assembly of Hexamers, Dihexamers, and Linear Multihexamer Structures by the Engineered Acylated Insulin Degludec. Biochemistry, 52, 2013
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4AJX
| Ligand controlled assembly of hexamers, dihexamers, and linear multihexamer structures by an engineered acylated insulin | Descriptor: | IMIDAZOLE, INSULIN, N-(16-Carboxyhexadecanoyl)-L-glutamic acid, ... | Authors: | Steensgaard, D.B, Schluckebier, G, Strauss, H.M, Norrman, M, Thomsen, J.K, Friderichsen, A.V, Havelund, S, Jonassen, I. | Deposit date: | 2012-02-20 | Release date: | 2013-01-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Ligand Controlled Assembly of Hexamers, Dihexamers, and Linear Multihexamer Structures by the Engineered Acylated Insulin Degludec. Biochemistry, 52, 2013
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6QRH
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6QRK
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4AIY
| R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 'GREEN' SUBSTATE, AVERAGE STRUCTURE | Descriptor: | PHENOL, PROTEIN (INSULIN) | Authors: | O'Donoghue, S.I, Chang, X, Abseher, R, Nilges, M, Led, J.J. | Deposit date: | 1998-12-29 | Release date: | 2000-02-28 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Unraveling the symmetry ambiguity in a hexamer: calculation of the R6 human insulin structure. J.Biomol.NMR, 16, 2000
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1W8P
| Structural properties of the B25Tyr-NMe-B26Phe insulin mutant. | Descriptor: | INSULIN A-CHAIN, INSULIN B-CHAIN, PHENOL, ... | Authors: | Zakowa, L, Au-Alvarez, O, Dodson, E.J, Dodson, G.G, Brzozowski, A.M. | Deposit date: | 2004-09-24 | Release date: | 2005-02-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Towards the Insulin-Igf-I Intermediate Structures: Functional and Structural Properties of the B25Tyr-Nme-B26Phe Insulin Mutant. Biochemistry, 43, 2004
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1VKT
| HUMAN INSULIN TWO DISULFIDE MODEL, NMR, 10 STRUCTURES | Descriptor: | INSULIN | Authors: | Hua, Q.X, Hu, S.Q, Frank, B.H, Jia, W.H, Chu, Y.C, Wang, S.H, Burke, G.T, Katsoyannis, P.G, Weiss, M.A. | Deposit date: | 1996-10-14 | Release date: | 1997-04-01 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue. J.Mol.Biol., 264, 1996
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1WAV
| CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN | Descriptor: | INSULIN, PHENOL, ZINC ION | Authors: | Liang, D.-C, Ding, J.-H, Chang, W.-R, Wan, Z.-L. | Deposit date: | 1996-02-28 | Release date: | 1997-02-28 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular replacement study on form-B monoclinic crystal of insulin. Sci.China, Ser.C: Life Sci., 39, 1996
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4A7E
| X-ray crystal structure of porcine insulin flash-cooled at high pressure | Descriptor: | INSULIN A CHAIN, INSULIN B CHAIN | Authors: | Burkhardt, A, Warmer, M, Panneerselvam, S, Wagner, A, Reimer, R, Hohenberg, H, Meents, A. | Deposit date: | 2011-11-14 | Release date: | 2011-11-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.856 Å) | Cite: | Fast High-Pressure Freezing of Protein Crystals in Their Mother Liquor Acta Crystallogr.,Sect.F, 68, 2012
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6S34
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3ZI3
| Crystal structure of the B24His-insulin - human analogue | Descriptor: | INSULIN, SULFATE ION | Authors: | Zakova, L, Kletvikova, E, Veverka, V, Lepsik, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. | Deposit date: | 2013-01-02 | Release date: | 2013-03-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Integrity of the B24 Site in Human Insulin is Important for Hormone Functionality J.Biol.Chem., 288, 2013
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1ZNI
| INSULIN | Descriptor: | CHLORIDE ION, INSULIN, ZINC ION | Authors: | Turkenburg, M.G.W, Whittingham, J.L, Dodson, G.G, Dodson, E.J, Xiao, B, Bentley, G.A. | Deposit date: | 1997-09-23 | Release date: | 1998-01-28 | Last modified: | 2018-07-04 | Method: | X-RAY DIFFRACTION (1.498 Å) | Cite: | Structure of insulin in 4-zinc insulin. Nature, 261, 1976
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1ZEI
| CROSS-LINKED B28 ASP INSULIN | Descriptor: | CHLORIDE ION, INSULIN, M-CRESOL, ... | Authors: | Whittingham, J.L, Edwards, E.J, Antson, A.A, Clarkson, J.M, Dodson, G.G. | Deposit date: | 1998-07-14 | Release date: | 1999-02-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Interactions of phenol and m-cresol in the insulin hexamer, and their effect on the association properties of B28 pro --> Asp insulin analogues. Biochemistry, 37, 1998
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6S4J
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6Q8Q
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3ZQR
| NMePheB25 insulin analogue crystal structure | Descriptor: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | Authors: | Antolikova, E, Zakova, L, Turkenburg, J.P, Watson, C.J, Hanclova, I, Sanda, M, Cooper, A, Kraus, T, Brzozowski, A.M, Jiracek, J.A. | Deposit date: | 2011-06-10 | Release date: | 2011-08-24 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Non-Equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface. J.Biol.Chem., 286, 2011
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