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7TRF
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BU of 7trf by Molmil
Human telomerase catalytic core RNP with H2A/H2B
Descriptor: Histone H2A, Histone H2B type 1-C/E/F/G/I, Telomerase RNA, ...
Authors:Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J.
Deposit date:2022-01-28
Release date:2022-04-20
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure of active human telomerase with telomere shelterin protein TPP1.
Nature, 604, 2022
6E53
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BU of 6e53 by Molmil
Structure of TERT in complex with a novel telomerase inhibitor
Descriptor: MAGNESIUM ION, RNA/DNA hairpin, Telomerase reverse transcriptase, ...
Authors:Hernandez-Sanchez, W, Huang, W, Plucinsky, B, Garcia-Vazquez, N, Berdis, A.J, Skordalakes, E, Taylor, D.J.
Deposit date:2018-07-19
Release date:2019-03-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity.
Plos Biol., 17, 2019
7UIM
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BU of 7uim by Molmil
CryoEM Structure of an Group II Intron Retroelement (apo-complex)
Descriptor: AMMONIUM ION, E.r IIC Intron, Group II intron reverse transcriptase/maturase, ...
Authors:Chung, K, Xu, L.
Deposit date:2022-03-29
Release date:2022-11-23
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structures of a mobile intron retroelement poised to attack its structured DNA target
Science, 378, 2022
7UIN
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BU of 7uin by Molmil
CryoEM Structure of an Group II Intron Retroelement
Descriptor: AMMONIUM ION, DNA (37-MER), E.r IIC Intron, ...
Authors:Chung, K, Xu, L.
Deposit date:2022-03-29
Release date:2022-11-23
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structures of a mobile intron retroelement poised to attack its structured DNA target
Science, 378, 2022
7KFU
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BU of 7kfu by Molmil
Cas6-RT-Cas1--Cas2 complex
Descriptor: Cas2, Cas6-RT-Cas1
Authors:Hoel, C.M, Wang, J.Y, Doudna, J.A, Brohawn, S.G.
Deposit date:2020-10-14
Release date:2021-03-31
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex.
Nat Commun, 12, 2021
7KFT
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BU of 7kft by Molmil
Partial Cas6-RT-Cas1--Cas2 complex
Descriptor: Cas2, Cas6-RT-Cas1
Authors:Hoel, C.M, Wang, J.Y, Doudna, J.A, Brohawn, S.G.
Deposit date:2020-10-14
Release date:2021-03-31
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex.
Nat Commun, 12, 2021
7KQN
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BU of 7kqn by Molmil
Ternary complex of TERT (telomerase reverse transcriptase) with RNA template, DNA primer, an incoming dGTP and a downstream hybrid duplex
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Choi, W.S, Weng, P.J, Yang, W.
Deposit date:2020-11-17
Release date:2022-03-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Flexibility of telomerase in binding the RNA template and DNA telomeric repeat.
Proc.Natl.Acad.Sci.USA, 119, 2022
7KQM
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BU of 7kqm by Molmil
Binary complex of TERT (telomerase reverse transcriptase) with RNA/telomeric DNA hybrid
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*TP*TP*CP*TP*TP*TP*GP*TP*GP*CP*AP*CP*CP*TP*G)-3'), ...
Authors:Choi, W.S, Weng, P.J, Yang, W.
Deposit date:2020-11-17
Release date:2022-03-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Flexibility of telomerase in binding the RNA template and DNA telomeric repeat.
Proc.Natl.Acad.Sci.USA, 119, 2022
8T2T
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BU of 8t2t by Molmil
Structure of a group II intron ribonucleoprotein in the post-ligation (post-2F) state
Descriptor: AMMONIUM ION, Group II intron reverse transcriptase/maturase, MAGNESIUM ION, ...
Authors:Xu, L, Liu, T, Chung, K, Pyle, A.M.
Deposit date:2023-06-06
Release date:2023-11-22
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into intron catalysis and dynamics during splicing.
Nature, 624, 2023
8T2R
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BU of 8t2r by Molmil
Structure of a group II intron ribonucleoprotein in the pre-ligation (pre-2F) state
Descriptor: 5'exon, AMMONIUM ION, CALCIUM ION, ...
Authors:Xu, L, Liu, T, Chung, K, Pyle, A.M.
Deposit date:2023-06-06
Release date:2023-11-22
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into intron catalysis and dynamics during splicing.
Nature, 624, 2023
8T2S
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BU of 8t2s by Molmil
Structure of a group II intron ribonucleoprotein in the pre-branching (pre-1F) state
Descriptor: AMMONIUM ION, CALCIUM ION, Group II intron reverse transcriptase/maturase, ...
Authors:Xu, L, Liu, T, Chung, K, Pyle, A.M.
Deposit date:2023-06-06
Release date:2023-11-22
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into intron catalysis and dynamics during splicing.
Nature, 624, 2023
8SXU
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BU of 8sxu by Molmil
Structure of LINE-1 ORF2p with an oligo(A) template
Descriptor: LINE-1 retrotransposable element ORF2 protein, RNA (25-MER)
Authors:van Eeuwen, T, Taylor, M.S, Rout, M.P.
Deposit date:2023-05-24
Release date:2024-01-10
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Structures, functions and adaptations of the human LINE-1 ORF2 protein.
Nature, 626, 2024
8SXT
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BU of 8sxt by Molmil
Structure of LINE-1 ORF2p with template:primer hybrid
Descriptor: DNA primer, LINE-1 retrotransposable element ORF2 protein, MAGNESIUM ION, ...
Authors:van Eeuwen, T, Taylor, M.S, Rout, M.P.
Deposit date:2023-05-24
Release date:2024-01-10
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures, functions and adaptations of the human LINE-1 ORF2 protein.
Nature, 626, 2024
8UW3
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BU of 8uw3 by Molmil
Human LINE-1 retrotransposon ORF2 protein engaged with template RNA in elongation state
Descriptor: Complementary DNA, LINE-1 retrotransposable element ORF2 protein, THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Thawani, A, Florez Ariza, A.J, Collins, K, Nogales, E.
Deposit date:2023-11-06
Release date:2023-12-20
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Template and target-site recognition by human LINE-1 in retrotransposition.
Nature, 626, 2024
4WE1
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BU of 4we1 by Molmil
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ600)
Descriptor: 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}naphthalene-2-carbonitrile, Gag-Pol polyprotein, MAGNESIUM ION, ...
Authors:Frey, K.M, Anderson, K.S.
Deposit date:2014-09-09
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.491 Å)
Cite:Picomolar Inhibitors of HIV-1 Reverse Transcriptase: Design and Crystallography of Naphthyl Phenyl Ethers.
Acs Med.Chem.Lett., 5, 2014
5XN2
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BU of 5xn2 by Molmil
HIV-1 reverse transcriptase Q151M:DNA:dGTP ternary complex
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 38-MER DNA aptamer, GLYCEROL, ...
Authors:Yasutake, Y, Tamura, N, Hayashi, H, Maeda, K.
Deposit date:2017-05-17
Release date:2018-02-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.381 Å)
Cite:HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir.
Sci Rep, 8, 2018
4ZHR
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BU of 4zhr by Molmil
Structure of HIV-1 RT Q151M mutant
Descriptor: RT p51 subunit, RT p66 subunit
Authors:Nakamura, A, Tamura, N, Yasutake, Y.
Deposit date:2015-04-27
Release date:2015-11-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Structure of the HIV-1 reverse transcriptase Q151M mutant: insights into the inhibitor resistance of HIV-1 reverse transcriptase and the structure of the nucleotide-binding pocket of Hepatitis B virus polymerase.
Acta Crystallogr.,Sect.F, 71, 2015
6HAK
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BU of 6hak by Molmil
Crystal structure of HIV-1 reverse transcriptase (RT) in complex with a double stranded RNA represents the RT transcription initiation complex prior to nucleotide incorporation
Descriptor: Gag-Pol polyprotein, MAGNESIUM ION, RNA (5'-R(P*AP*GP*UP*GP*GP*CP*GP*GP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*C)-3'), ...
Authors:Das, K, Martinez, S.E, Arnold, E.
Deposit date:2018-08-07
Release date:2019-04-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.95 Å)
Cite:Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation.
Proc.Natl.Acad.Sci.USA, 116, 2019
5OVN
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BU of 5ovn by Molmil
Crystal Structure of FIV Reverse Transcriptase
Descriptor: POL protein
Authors:Galilee, M, Alian, A.
Deposit date:2017-08-29
Release date:2018-01-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.942 Å)
Cite:The structure of FIV reverse transcriptase and its implications for non-nucleoside inhibitor resistance.
PLoS Pathog., 14, 2018
7KRD
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BU of 7krd by Molmil
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 4-(3-chloro-5-cyanophenoxy)-3-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenyl sulfurofluoridate (JLJ702)
Descriptor: 4-(3-chloro-5-cyanophenoxy)-3-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenyl sulfurofluoridate, HIV-1 REVERSE TRANSCRIPTASE, P51 SUBUNIT, ...
Authors:Bertoletti, N, Ippolito, J.A, Jorgensen, W.L, Anderson, K.S.
Deposit date:2020-11-19
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead.
Acs Med.Chem.Lett., 12, 2021
6P2G
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BU of 6p2g by Molmil
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and D-ddCTP
Descriptor: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA Primer 20-mer, DNA template 27-mer, ...
Authors:Bertoletti, N, Anderson, K.S.
Deposit date:2019-05-21
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci., 28, 2019
5K14
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BU of 5k14 by Molmil
HIV-1 Reverse Transcriptase in complex with a 2,6-difluorophenyl DAPY analog
Descriptor: 4-{[4-(2,6-difluoro-4-methoxybenzene-1-carbonyl)pyrimidin-2-yl]amino}benzonitrile, HIV-1 reverse transcriptase (isolate LW123), HIV-1 reverse transcriptase(isolate HXB2)
Authors:Lansdon, E.B.
Deposit date:2016-05-17
Release date:2016-06-29
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Novel (2,6-difluorophenyl)(2-(phenylamino)pyrimidin-4-yl)methanones with restricted conformation as potent non-nucleoside reverse transcriptase inhibitors against HIV-1.
Eur.J.Med.Chem., 122, 2016
1QE1
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BU of 1qe1 by Molmil
CRYSTAL STRUCTURE OF 3TC-RESISTANT M184I MUTANT OF HIV-1 REVERSE TRANSCRIPTASE
Descriptor: REVERSE TRANSCRIPTASE, SUBUNIT P51, SUBUNIT P66
Authors:Sarafianos, S.G, Das, K, Ding, J, Hughes, S.H, Arnold, E.
Deposit date:1999-07-12
Release date:1999-08-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.
Proc.Natl.Acad.Sci.USA, 96, 1999
6P1I
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BU of 6p1i by Molmil
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and dCTP
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA Primer 20-mer, DNA template 27-mer, ...
Authors:Bertoletti, N, Anderson, K.S.
Deposit date:2019-05-19
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci., 28, 2019
7O24
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BU of 7o24 by Molmil
Structure of the foamy viral protease-reverse transcriptase in complex with dsDNA.
Descriptor: DNA (5'-D(*AP*AP*CP*AP*GP*AP*GP*TP*GP*CP*GP*AP*CP*AP*CP*CP*TP*GP*AP*TP*TP*CP*CP*A)-3'), DNA (5'-D(*TP*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*GP*CP*AP*CP*TP*CP*TP*G)-3'), Pr125Pol
Authors:Nowotny, M, Czarnocki-Cieciura, M.
Deposit date:2021-03-30
Release date:2021-06-30
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structures of Substrate Complexes of Foamy Viral Protease-Reverse Transcriptase.
J.Virol., 95, 2021

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PDB entries from 2024-09-18

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